Variation and Interdependencies of Human Milk Macronutrients, Fatty Acids, Adiponectin, Insulin, and IGF-II in the European PreventCD Cohort

被引：19

作者：

Grunewald, Maria ^{[1
]}

Hellmuth, Christian ^{[1
]}

Kirchberg, Franca F. ^{[1
]}

Mearin, Maria Luisa ^{[2
]}

Auricchio, Renata ^{[3
,4
]}

Castillejo, Gemma ^{[5
]}

Korponay-Szabo, Ilma R. ^{[6
]}

Polanco, Isabel ^{[7
]}

Roca, Maria ^{[8
]}

Vriezinga, Sabine L. ^{[2
]}

Werkstetter, Katharina ^{[1
]}

Koletzko, Berthold ^{[1
]}

Demmelmair, Hans ^{[1
]}

机构：

[1] Univ Munich, Ludwig Maximilians Univ, Dr Von Hauner Childrens Hosp, Div Metab & Nutrit Med,Med Ctr, D-80337 Munich, Germany

[2] Leiden Univ, Med Ctr, Dept Paediat, NL-2300 Leiden, Netherlands

[3] Univ Federico II, European Lab Investigat Food Induced Dis, I-80131 Naples, Italy

[4] Univ Federico II, Dept Med Translat Sci, I-80131 Naples, Italy

[5] Hosp Univ Sant Joan Reus, Dept Pediat Gastroenterol, URV, IIPV, Reus 43201, Spain

[6] Heim Pal Childrens Hosp, Celiac Dis Ctr, H-1089 Budapest, Hungary

[7] La Paz Univ Hosp, Dept Pediat Gastroenterol & Nutr, Madrid 28033, Spain

[8] Inst Investigac Sanitaria La Fa, U Enfermedad Celiaca Inmunopatol Digestiva, Valencia 46026, Spain

来源：

NUTRIENTS | 2019年 / 11卷 / 09期

基金：

欧洲研究理事会;

关键词：

human milk; celiac disease; hormones; fatty acids; duration of lactation; country; carbohydrate; fat; CELIAC-DISEASE PATIENTS; BREAST-MILK; GROWTH-FACTORS; DOCOSAHEXAENOIC ACID; 1ST YEAR; PROTEIN; DIET; LACTATION; INFANT; METABOLISM;

D O I：

10.3390/nu11092034

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Human milk composition is variable. The identification of influencing factors and interdependencies of components may help to understand the physiology of lactation. In this study, we analyzed linear trends in human milk composition over time, the variation across different European countries and the influence of maternal celiac disease. Within a multicenter European study exploring potential prevention of celiac disease in a high-risk population (PreventCD), 569 human milk samples were donated by women from five European countries between 16 and 163 days postpartum. Some 202 mothers provided two samples at different time points. Protein, carbohydrates, fat and fatty acids, insulin, adiponectin, and insulin-like growth factor II (IGF-II) were analyzed. Milk protein and n-6 long chain polyunsaturated fatty acids decreased during the first three months of lactation. Fatty acid composition was significantly influenced by the country of residence. IGF-II and adiponectin concentrations correlated with protein content (r = 0.24 and r = 0.35), and IGF-II also correlated with fat content (r = 0.36), suggesting a possible regulatory role of IGF in milk macronutrient synthesis. Regarding the impact of celiac disease, only the level in palmitic acid was influenced by this disease, suggesting that breastfeeding by celiac disease mothers should not be discouraged.

引用

页数：19