Southwestern Japan lies at the boundary between the subducting Philippine Sea plate and the overriding Eurasian plate. A magnitude 8 megathrust earthquake ruptured the Tonankai and Nankai segments in 1944 and 1946, respectively, but the neighbouring Tokai segment of the plate boundary remained locked(1). A large megathrust earthquake in the Tokai region has therefore been expected. In 2009, a magnitude 6.4 earthquake took place in Suruga Bay, within the Philippine Sea subducting plate, close to the Tokai segment. Here, we use a fault-slip model to examine the impact of the stress changes(2) caused by the Suruga Bay event on the Tokai segment. We show that the occurrence rate of plate-boundary seismicity increased following the earthquake. Most of the presumed strongly locked patches of the Tokai segment are located within areas of increased stress. Rupturing of a locked patch-following a threshold level of seismic stress-could trigger the rupture of the entire Tokai segment, leading to a megathrust earthquake.