Cycling with BRCA2 from DNA repair to mitosis

被引：21

作者：

Lee, Hyunsook ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Dept Biol Sci, Seoul 151742, South Korea

[2] Seoul Natl Univ, Inst Mol Biol & Genet, Seoul 151742, South Korea

来源：

EXPERIMENTAL CELL RESEARCH | 2014年 / 329卷 / 01期

关键词：

BRCA2; HDR (homology-directed recombination); Replication fork; Spindle assembly checkpoint (SAC); Cell cycle; CANCER SUSCEPTIBILITY GENE; SPINDLE ASSEMBLY CHECKPOINT; STRAND BREAK REPAIR; BUBR1; ACETYLATION; FANCONI-ANEMIA; HOMOLOGOUS RECOMBINATION; PROTEIN BRCA2; RAD51; REPLICATION; CELLS;

D O I：

10.1016/j.yexcr.2014.10.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts distinct functions in a cell-cycle specific manner in the maintenance of genomic integrity. (C) 2014 The Author. Published by Elsevier Inc.

引用

页码：78 / 84

页数：7

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