Structure, regulation, and host interaction of outer membrane protein U (OmpU) of Vibrio species

被引：18

作者：

Ganie, Hilal A. ^{[1
]}

Choudhary, Aaina ^{[1
]}

Baranwal, Somesh ^{[1
]}

机构：

[1] Cent Univ Punjab, Sch Basic Sci, Dept Microbiol, Room 522,South Block,Acad Bldg, Bathinda 151401, Punjab, India

来源：

MICROBIAL PATHOGENESIS | 2022年 / 162卷

关键词：

Virulence; Innate immunity; Disease progression; Vaccine; NF kappa B; CHOLERAE PORINS OMPU; CROSS-PROTECTION; EXPRESSION; VACCINE; GENE; IDENTIFICATION; ACTIVATION; RECOGNITION; RESISTANCE; TOLERANCE;

D O I：

10.1016/j.micpath.2021.105267

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

OmpU is a multimeric, cation selective outer membrane protein of Vibrio and related species that non-covalently interact with peptidoglycan layer. Interaction of OmpU with human host cells triggers signaling pathways to promote cytokine secretion, reactive oxygen species production, and caspase independent death in immune and epithelial cells. Non-choleric OmpU imparts resistance to antimicrobial peptides and induces actin cytoskeletal reorganization in the host cells. Further, OmpU isolated from Vibrio species elicits an immune response in several aquaculture hosts. Importantly, in-vivo studies using recombinant OmpU or OmpU derived mimotopes reveal a short-lasting immunity, and protection against Vibrio in the aquaculture sector. In conclusion, OmpU is a key adhesion protein and an important virulence factor for successful colonization of Vibrio species into hosts. This review article provides a broad overview of structural, regulatory, and functional mechanisms of OmpU in normal and disease states.

引用

页数：8

共 55 条

[1] Vibrio fischeri outer membrane protein OmpU plays a role in normal symbiotic colonization [J].