Cell adhesion in regulation of asymmetric stem cell division

被引:32
作者
Yamashita, Yukiko M. [1 ]
机构
[1] Univ Michigan, Inst Life Sci, Ctr Stem Cell Biol, Dept Cell & Dev Biol,Cellular & Mol Biol Program, Ann Arbor, MI 48109 USA
关键词
MUSCLE SATELLITE CELLS; DROSOPHILA TESTIS; SELF-RENEWAL; NEURAL STEM; ADHERENS JUNCTIONS; FATE DETERMINATION; NICHE; CENTROSOME; OVARY; DIFFERENTIATION;
D O I
10.1016/j.ceb.2010.07.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Adult stem cells inevitably communicate with their cellular neighbors within the tissues they sustain. Indeed, such communication, particularly with components of the stem cell niche, is essential for many aspects of stem cell behavior, including the maintenance of stem cell identity and asymmetric cell division. Cell adhesion mediates this communication by placing stem cells in proximity to the signaling source and by providing a polarity cue that orients stem cells. Here, I review the recent discovery that cell adhesion molecules govern the behavior of stem cells.
引用
收藏
页码:605 / 610
页数:6
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