Identification and Antifungal Activity of Compounds from the Mangrove Endophytic Fungus Aspergillus clavatus R7

被引:33
作者
Li, Wensheng [1 ]
Xiong, Ping [1 ]
Zheng, Wenxu [1 ]
Zhu, Xinwei [1 ]
She, Zhigang [2 ]
Ding, Weijia [1 ]
Li, Chunyuan [1 ]
机构
[1] South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
来源
MARINE DRUGS | 2017年 / 15卷 / 08期
基金
中国国家自然科学基金;
关键词
mangrove endophytic fungus; coumarin; chromone; sterone; antifungal activity; Aspergillus clavatus; TAXUS-MAIREI;
D O I
10.3390/md15080259
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Two new coumarin derivatives, 4,4'-dimethoxy-5,5'-dimethyl-7,7'-oxydicoumarin (1), 7-(gamma,gamma-dimethylallyloxy)-5-methoxy-4-methylcoumarin (2), a new chromone derivative, (S)-5-hydroxy-2,6-dimethyl-4H-furo[3,4-g] benzopyran-4,8(6H)-dione (5), and a new sterone derivative, 24-hydroxylergosta-4,6,8(14), 22-tetraen-3-one (6), along with two known bicoumarins, kotanin (3) and orlandin (4), were isolated from an endophytic fungus Aspergillus clavatus (collection No. R7), isolated from the root of Myoporum bontioides collected from Leizhou Peninsula, China. Their structures were elucidated using 1D-and 2D-NMR spectroscopy, and HRESIMS. The absolute configuration of compound 5 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Compound 6 significantly inhibited the plant pathogenic fungi Fusarium oxysporum, Colletotrichum musae and Penicillium italicum, compound 5 significantly inhibited Colletotrichum musae, and compounds 1, 3 and 4 greatly inhibited Fusarium oxysporum, showing the antifungal activities higher than those of the positive control, triadimefon.
引用
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页数:10
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