Asymmetric PPCys: Strongly fluorescing NIR labels

被引：78
作者：
Fischer, Georg Michael
Juengst, Christian
Isomaeki-Krondahl, Magnus
Gauss, Dominik
Moeller, Heiko Michael
Daltrozzo, Ewald
Zumbusch, Andreas [1 ]
机构：
[1] Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 29期
关键词：
CELL-PENETRATING PEPTIDES; NEAR-INFRARED DYES; FLUOROPHORES; PROBES; TUMORS;
D O I：
10.1039/c0cc00359j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
By a stepwise synthesis strategy biofunctionalized Pyrrolopyrrole Cyanines (PPCy) with an asymmetric substitution pattern were obtained. These exhibit extremely strong and narrowband NIR absorption and fluorescence. Internalization of a peptide bound PPCy is demonstrated using live cell microscopy.
引用
收藏
页码：5289 / 5291
页数：3
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