Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

被引：5
作者：
Price, Jennifer C. [1 ]
Seaberg, Eric C. [2 ]
Phair, John P. [3 ]
Witt, Mallory D. [4 ]
Koletar, Susan L. [5 ]
Thio, Chloe L. [6 ]
机构：
[1] Univ Calif San Francisco, Dept Med, Div Gastroenterol & Hepatol, 513 Parnassus Ave,S-357, San Francisco, CA 94143 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[3] Northwestern Univ, Dept Med, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles Biomed Res Inst,Harbor UCLA, Torrance, CA USA
[5] Ohio State Univ, Dept Med, Div Infect Dis, Columbus, OH 43210 USA
[6] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期
基金：
美国国家卫生研究院;
关键词：
HIV; HBV; HCV; antiviral therapy; liver; hepatitis; APRI; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; MULTICENTER AIDS COHORT; PLATELET RATIO INDEX; FIBROSIS PROGRESSION; MONOINFECTED PATIENTS; COINFECTED PATIENTS; NONINVASIVE INDEX; HUMAN HEPATOCYTES; VIRAL-HEPATITIS;
D O I：
10.1097/QAI.0000000000000981
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre-and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.
引用
收藏
页码：319 / 323
页数：5
相关论文
共 50 条
  • [41] HIV Reservoir Dynamics in the Face of Highly Active Antiretroviral Therapy
    Costiniuk, Cecilia T.
    Jenabian, Mohammad-Ali
    [J]. AIDS PATIENT CARE AND STDS, 2015, 29 (02) : 55 - 68
  • [42] Highly active antiretroviral therapy and cervical cytologic abnormalities among women with HIV infection in a limited-resource setting
    Ugboaja, Joseph O.
    Oguejiofor, Charlotte Blanche
    Ogelle, Onyecherelam M.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2018, 140 (02) : 228 - 232
  • [43] Endothelial markers and HIV infection in the era of highly active antiretroviral treatment
    de Larrañaga, GF
    Bocassi, AR
    Puga, LM
    Alonso, BS
    Benetucci, JA
    [J]. THROMBOSIS RESEARCH, 2003, 110 (2-3) : 93 - 98
  • [44] Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function
    Ferrando, S
    van Gorp, W
    McElhiney, M
    Goggin, K
    Sewell, M
    Rabkin, J
    [J]. AIDS, 1998, 12 (08) : F65 - F70
  • [45] Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy
    Price, P
    Mathiot, N
    Krueger, R
    Stone, S
    Keane, NM
    French, MA
    [J]. JOURNAL OF CLINICAL VIROLOGY, 2001, 22 (03) : 279 - 287
  • [46] Langerhans cells in periodontal disease of HIV- and HIV plus patients undergoing highly active antiretroviral therapy
    Segundo, Takeshi Kato
    Sauto, Giovanna Ribeiro
    Mesquita, Ricardo Alves
    Costa, Fernando Oliveira
    [J]. BRAZILIAN ORAL RESEARCH, 2011, 25 (03): : 255 - 260
  • [47] Mast Cells in Periodontal Disease of Individuals With and Without HIV Undergoing Highly Active Antiretroviral Therapy
    Segundo, Takeshi Kato
    Souto, Giovanna Ribeiro
    Costa, Fernando Oliveira
    Mesquita, Ricardo Alves
    [J]. JOURNAL OF PERIODONTOLOGY, 2013, 84 (07) : 995 - 1001
  • [48] Metabolic and morphologic disorders in patients treated with highly active antiretroviral therapy since primary HIV infection
    Narciso, P
    Tozzi, V
    D'Offizi, G
    De Carli, G
    Orchi, N
    Galati, V
    Vincenzi, L
    Bellagamba, R
    Carvelli, C
    Puro, V
    [J]. HIV-ASSOCIATED CARDIOVASCULAR DISEASE: CLINICAL AND BIOLOGICAL INSIGHTS, 2001, 946 : 214 - 222
  • [49] Risk factors for Blastocystis infection in HIV/AIDS patients with highly active antiretroviral therapy in Southwest China
    Zhang, Shun-Xian
    Kang, Fen-Yan
    Chen, Jia-Xu
    Tian, Li-Guang
    Geng, Lan-Lan
    [J]. INFECTIOUS DISEASES OF POVERTY, 2019, 8 (01)
  • [50] Oral manifestations of HIV infection in patients receiving highly active antiretroviral therapy (HAART) in Bahia, Brazil
    Lima da Silva, Carlos Alberto
    Dourado, Ines
    Dahia, Samir Resack
    Harzheim, Erno
    Rutherford, George Williams
    [J]. JOURNAL OF PUBLIC HEALTH DENTISTRY, 2008, 68 (03) : 178 - 181
12345