Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

被引：5
|
作者：
Price, Jennifer C. [1 ]
Seaberg, Eric C. [2 ]
Phair, John P. [3 ]
Witt, Mallory D. [4 ]
Koletar, Susan L. [5 ]
Thio, Chloe L. [6 ]
机构：
[1] Univ Calif San Francisco, Dept Med, Div Gastroenterol & Hepatol, 513 Parnassus Ave,S-357, San Francisco, CA 94143 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[3] Northwestern Univ, Dept Med, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles Biomed Res Inst,Harbor UCLA, Torrance, CA USA
[5] Ohio State Univ, Dept Med, Div Infect Dis, Columbus, OH 43210 USA
[6] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期
基金：
美国国家卫生研究院;
关键词：
HIV; HBV; HCV; antiviral therapy; liver; hepatitis; APRI; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; MULTICENTER AIDS COHORT; PLATELET RATIO INDEX; FIBROSIS PROGRESSION; MONOINFECTED PATIENTS; COINFECTED PATIENTS; NONINVASIVE INDEX; HUMAN HEPATOCYTES; VIRAL-HEPATITIS;
D O I：
10.1097/QAI.0000000000000981
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre-and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.
引用
收藏
页码：319 / 323
页数：5
相关论文
共 50 条
  • [21] Possible association of sialolithiasis with HIV infection and highly active antiretroviral therapy: A case report
    Brooks, John K.
    Jones, Joyce L.
    Price, Jeffery B.
    SPECIAL CARE IN DENTISTRY, 2020, 40 (03) : 298 - 302
  • [22] Venous and Arterial Thromboembolic Complications Associated with HIV Infection and Highly Active Antiretroviral Therapy
    Auerbach, Evan
    Aboulafia, David M.
    SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2012, 38 (08) : 830 - 838
  • [23] Rheumatic manifestations associated with HIV in the highly active antiretroviral therapy era
    Nguyen, Binh Y.
    Reveille, John D.
    CURRENT OPINION IN RHEUMATOLOGY, 2009, 21 (04) : 404 - 410
  • [24] HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review
    Lambert, C. T.
    Sandesara, P. B.
    Hirsh, B.
    Shaw, L. J.
    Lewis, W.
    Quyyumi, A. A.
    Schinazi, R. F.
    Post, W. S.
    Sperling, L.
    HIV MEDICINE, 2016, 17 (06) : 411 - 424
  • [25] Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital
    Galisteu, Katia Jaira
    Cardoso, Luciana Ventura
    da Cruz Furini, Adriana Antonia
    Schiesari Junior, Arlindo
    Cesarino, Claudia Bernardi
    Franco, Celia
    de Souza Baptista, Andrea Regina
    Dantas Machado, Ricardo Luiz
    REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2015, 48 (02) : 149 - 156
  • [26] Antiretroviral Effects on HBV/HIV Co-infection and the Natural History of Liver Disease
    Wyles, David L.
    CLINICS IN LIVER DISEASE, 2019, 23 (03) : 473 - +
  • [27] Effects of highly active antiretroviral therapy (HAART) on psychomotor performance in children with HIV disease
    Koekkoek, Sanneke
    Eggermont, Laura
    De Sonneville, Leo
    Jupimai, Thidakat
    Wicharuk, Saijai
    Apateerapong, Wichitea
    Chuenyam, Theshinee
    Lange, Joep
    Wit, Ferdinand
    Pancharoen, Chitsanu
    Phanuphak, Praphan
    Ananworanich, Jintanat
    JOURNAL OF NEUROLOGY, 2006, 253 (12) : 1615 - 1624
  • [28] Effects of highly active antiretroviral therapy (HAART) on psychomotor performance in children with HIV disease
    Sanneke Koekkoek
    Laura Eggermont
    Leo De Sonneville
    Thidakat Jupimai
    Saijai Wicharuk
    Wichitea Apateerapong
    Theshinee Chuenyam
    Joep Lange
    Ferdinand Wit
    Chitsanu Pancharoen
    Praphan Phanuphak
    Jintanat Ananworanich
    Journal of Neurology, 2006, 253 : 1615 - 1624
  • [29] Disease-Modifying Therapeutic Concepts for HIV in the Era of Highly Active Antiretroviral Therapy
    Butler, Scott L.
    Valdez, Hernan
    Westby, Michael
    Perros, Manos
    June, Carl H.
    Jacobson, Jeffrey M.
    Levy, Yves
    Cooper, David A.
    Douek, Daniel
    Lederman, Michael M.
    Tebas, Pablo
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 58 (03) : 297 - 303
  • [30] Cerebrovascular disease in HIV-infected individuals in the era of highly active antiretroviral therapy
    Belinda Cruse
    Lucette A. Cysique
    Romesh Markus
    Bruce J. Brew
    Journal of NeuroVirology, 2012, 18 : 264 - 276
12345