Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection

被引：5
|
作者：
Price, Jennifer C. [1 ]
Seaberg, Eric C. [2 ]
Phair, John P. [3 ]
Witt, Mallory D. [4 ]
Koletar, Susan L. [5 ]
Thio, Chloe L. [6 ]
机构：
[1] Univ Calif San Francisco, Dept Med, Div Gastroenterol & Hepatol, 513 Parnassus Ave,S-357, San Francisco, CA 94143 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[3] Northwestern Univ, Dept Med, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles Biomed Res Inst,Harbor UCLA, Torrance, CA USA
[5] Ohio State Univ, Dept Med, Div Infect Dis, Columbus, OH 43210 USA
[6] Johns Hopkins Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期
基金：
美国国家卫生研究院;
关键词：
HIV; HBV; HCV; antiviral therapy; liver; hepatitis; APRI; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; MULTICENTER AIDS COHORT; PLATELET RATIO INDEX; FIBROSIS PROGRESSION; MONOINFECTED PATIENTS; COINFECTED PATIENTS; NONINVASIVE INDEX; HUMAN HEPATOCYTES; VIRAL-HEPATITIS;
D O I：
10.1097/QAI.0000000000000981
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre-and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.
引用
收藏
页码：319 / 323
页数：5
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