From melanocytes to melanomas

被引：606
作者：
Shain, A. Hunter [1 ,2 ,3 ]
Bastian, Boris C.
机构：
[1] Univ Calif San Francisco, Dept Dermatol, Box 3111, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pathol, Box 3111, San Francisco, CA 94143 USA
[3] Helen Diller Family Comprehens Canc Ctr, Box 3111, San Francisco, CA 94143 USA
来源：
NATURE REVIEWS CANCER | 2016年 / 16卷 / 06期
基金：
美国国家卫生研究院;
关键词：
CUTANEOUS MALIGNANT-MELANOMA; TUMOR-CELL PROLIFERATION; TERT PROMOTER MUTATIONS; NEVI FREQUENTLY HARBOR; BRAF MUTATIONS; DYSPLASTIC NEVI; DNA-DAMAGE; LENTIGO MALIGNA; RISK-FACTOR; IN-SITU;
D O I：
10.1038/nrc.2016.37
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic neoplasm can also be staged by how far it has progressed, ranging from a benign neoplasm, such as a naevus, to a malignant neoplasm, such as a metastatic melanoma. Each subtype of melanoma can evolve through distinct evolutionary trajectories, passing through (or sometimes skipping over) various stages of transformation. This Review delineates several of the more common progression trajectories that occur in the patient setting and proposes models for tumour evolution that integrate genetic, histopathological, clinical and biological insights from the melanoma literature.
引用
收藏
页码：345 / 358
页数：14
相关论文
共 175 条
[41]   Clinical Decision Making Based on Histopathologic Grading and Margin Status of Dysplastic Nevi [J].
Duffy, Keith L. ;
Mann, David J. ;
Petronic-Rosic, Vesna ;
Shea, Christopher R. .
ARCHIVES OF DERMATOLOGY, 2012, 148 (02) :259-260
[42]   Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma [J].
Dutton-Regester, Ken ;
Kakavand, Hojabr ;
Aoude, Lauren G. ;
Stark, Mitchell S. ;
Gartside, Michael G. ;
Johansson, Peter ;
O'Connor, Linda ;
Lanagan, Cathy ;
Tembe, Varsha ;
Pupo, Gulietta M. ;
Haydu, Lauren E. ;
Schmidt, Christopher W. ;
Mann, Graham J. ;
Thompson, John F. ;
Scolyer, Richard A. ;
Hayward, Nicholas K. .
PIGMENT CELL & MELANOMA RESEARCH, 2013, 26 (06) :852-860
[43]  
Elder DE., 1991, Melanocytic tumors of the skin
[44]   SITE-SPECIFIC MELANOCYTIC NEVUS COUNTS AS PREDICTORS OF WHOLE-BODY NAEVI [J].
ENGLISH, JSC ;
SWERDLOW, AJ ;
MACKIE, RM ;
ODOHERTY, CJ ;
HUNTER, JAA ;
CLARK, J ;
HOLE, DJ .
BRITISH JOURNAL OF DERMATOLOGY, 1988, 118 (05) :641-644
[45]   Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists [J].
Farmer, ER ;
Gonin, R ;
Hanna, MP .
HUMAN PATHOLOGY, 1996, 27 (06) :528-531
[46]   Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer [J].
Fisher, B ;
Anderson, S ;
Bryant, J ;
Margolese, RG ;
Deutsch, M ;
Fisher, ER ;
Jeong, J ;
Wolmark, N .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (16) :1233-1241
[47]   Proliferation, apoptosis, and survivin expression in a spectrum of melanocytic nevi [J].
Florell, SR ;
Bowen, AR ;
Hanks, AN ;
Murphy, KJ ;
Grossman, D .
JOURNAL OF CUTANEOUS PATHOLOGY, 2005, 32 (01) :45-49
[48]   Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma [J].
Gartner, Jared J. ;
Davis, Sean ;
Wei, Xiaomu ;
Lin, Jimmy C. ;
Trivedi, Niraj S. ;
Teer, Jamie K. ;
Meltzer, Paul S. ;
Rosenberg, Steven A. ;
Samuels, Yardena .
BMC GENOMICS, 2012, 13
[49]   Fluorescence in Situ Hybridization for Distinguishing Nevoid Melanomas From Mitotically Active Nevi [J].
Gerami, Pedram ;
Wass, Amanda ;
Mafee, Mariam ;
Fang, Yuaquin ;
Pulitzer, Melissa P. ;
Busam, Klaus J. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (12) :1783-1788
[50]   Frequent Mitotic Activity in Banal Melanocytic Nevi Uncovered by Immunohistochemical Analysis [J].
Glatz, Katharina ;
Hartmann, Christoph ;
Antic, Milos ;
Kutzner, Heinz .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2010, 32 (07) :643-649
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