From melanocytes to melanomas

被引：606

作者：

Shain, A. Hunter ^{[1
,2
,3
]}

Bastian, Boris C.

机构：

[1] Univ Calif San Francisco, Dept Dermatol, Box 3111, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pathol, Box 3111, San Francisco, CA 94143 USA

[3] Helen Diller Family Comprehens Canc Ctr, Box 3111, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 06期

基金：

美国国家卫生研究院;

关键词：

CUTANEOUS MALIGNANT-MELANOMA; TUMOR-CELL PROLIFERATION; TERT PROMOTER MUTATIONS; NEVI FREQUENTLY HARBOR; BRAF MUTATIONS; DYSPLASTIC NEVI; DNA-DAMAGE; LENTIGO MALIGNA; RISK-FACTOR; IN-SITU;

D O I：

10.1038/nrc.2016.37

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic neoplasm can also be staged by how far it has progressed, ranging from a benign neoplasm, such as a naevus, to a malignant neoplasm, such as a metastatic melanoma. Each subtype of melanoma can evolve through distinct evolutionary trajectories, passing through (or sometimes skipping over) various stages of transformation. This Review delineates several of the more common progression trajectories that occur in the patient setting and proposes models for tumour evolution that integrate genetic, histopathological, clinical and biological insights from the melanoma literature.

引用

页码：345 / 358

页数：14

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