Lipid metabolism is dysregulated in a mouse model of diabetes

被引：12
作者：
Furse, Samuel [1 ,2 ,3 ]
机构：
[1] Univ Cambridge, Addenbrookes Treatment Ctr, Wellcome MRC Inst Metab Sci, Core Metabol & Lipid Lab, Keith Day Rd, Cambridge CB2 0QQ, England
[2] Univ Cambridge, Addenbrookes Treatment Ctr, Wellcome MRC Inst Metab Sci, Metab Dis Unit, Keith Day Rd, Cambridge CB2 0QQ, England
[3] Royal Bot Gardens Kew, Jodrell Lab, Richmond TW9 3SD, Surrey, England
来源：
METABOLOMICS | 2022年 / 18卷 / 06期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Lipid traffic analysis; T2DM; Lipid metabolism;
D O I：
10.1007/s11306-022-01884-w
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Much evidence for diabetes mellitus being associated with dysregulated lipid metabolism has been accrued from studies using blood plasma. However, the systemic dysregulation these results point to is not understood. This study used Lipid Traffic Analysis on data from a mouse model of diabetes to test the hypothesis that the systemic control of lipid metabolism differed in a model of diabetes. This provided eidence for changes in the systemic control of both triglyceride and phospholipid metabolism that were not attributable to dietary intake. This supports the conclusion that diabetes is a systemic condition associated with dysregulated lipid metabolism through several pathways.
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收藏
页数：6
相关论文
共 19 条
[1]  
ALEJANDRO R, 1988, J AM VET MED ASSOC, V193, P1050
[2]   Comprehensive lipidomic profiling in serum and multiple tissues from a mouse model of diabetes [J].
Chen, Zhen ;
Liang, Qiangrong ;
Wu, Yue ;
Gao, Zijun ;
Kobayashi, Satoru ;
Patel, Joy ;
Li, Cairong ;
Cai, Fei ;
Zhang, Youhua ;
Liang, Chongsheng ;
Chiba, Hitoshi ;
Hui, Shu-Ping .
METABOLOMICS, 2020, 16 (11)
[3]   The shared risk of diabetes between dog and cat owners and their pets: register based cohort study [J].
Delicano, Rachel Ann ;
Hammar, Ulf ;
Egenvall, Agneta ;
Westgarth, Carri ;
Mubanga, Mwenya ;
Byberg, Liisa ;
Fall, Tove ;
Kennedy, Beatrice .
BMJ-BRITISH MEDICAL JOURNAL, 2020, 371
[4]  
Foundation I.D., 2021, IDF DIABETES ATLAS, V10
[5]   A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia [J].
Furse, Samuel ;
Fernandez-Twinn, Denise S. ;
Beeson, Jessica H. ;
Chiarugi, Davide ;
Ozanne, Susan E. ;
Koulman, Albert .
NUTRITION & DIABETES, 2022, 12 (01)
[6]   Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma [J].
Furse, Samuel ;
Watkins, Adam J. ;
Williams, Huw E. L. ;
Snowden, Stuart G. ;
Chiarugi, Davide ;
Koulman, Albert .
METABOLOMICS, 2022, 18 (02)
[7]   Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes [J].
Furse, Samuel ;
Fernandez-Twinn, Denise S. ;
Chiarugi, Davide ;
Koulman, Albert ;
Ozanne, Susan E. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
[8]   Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings' lipid metabolism [J].
Furse, Samuel ;
Watkins, Adam J. ;
Hojat, Nima ;
Smith, James ;
Williams, Huw E. L. ;
Chiarugi, Davide ;
Koulman, Albert .
COMMUNICATIONS BIOLOGY, 2021, 4 (01)
[9]   Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy [J].
Furse, Samuel ;
White, Sara L. ;
Meek, Claire L. ;
Jenkins, Benjamin ;
Petry, Clive J. ;
Vieira, Matias C. ;
Ozanne, Susan E. ;
Dunger, David B. ;
Poston, Lucilla ;
Koulman, Albert .
MOLECULAR OMICS, 2019, 15 (06) :420-430
[10]   Clusters of fatty acids in the serum triacylglyceride fraction associate with the disorders of type 2 diabetes [J].
Johnston, Luke W. ;
Liu, Zhen ;
Retnakaran, Ravi ;
Zinman, Bernard ;
Giacca, Adria ;
Harris, Stewart B. ;
Bazinet, Richard P. ;
Hanley, Anthony J. .
JOURNAL OF LIPID RESEARCH, 2018, 59 (09) :1751-1762
12