FOXD1 Expression Is Associated with Poor Prognosis in Non-small Cell Lung Cancer

被引：4
|
作者：
Nakayama, Sohei [1 ]
Soejima, Kenzo [1 ]
Yasuda, Hiroyuki [1 ]
Yoda, Satoshi [1 ]
Satomi, Ryosuke [1 ]
Ikemura, Shinnosuke [1 ]
Terai, Hideki [1 ]
Sato, Takashi [1 ]
Yamaguchi, Norihiro [2 ]
Hamamoto, Junko [1 ]
Arai, Daisuke [1 ]
Ishioka, Kota [1 ]
Ohgino, Keiko [1 ]
Naoki, Katsuhiko [1 ,3 ]
Betsuyaku, Tomoko [1 ]
机构：
[1] Keio Univ, Sch Med, Dept Med, Div Pulm Med, Tokyo 1608582, Japan
[2] Beth Israel Deaconess Med Ctr, Dept Internal Med, New York, NY USA
[3] Keio Univ Hosp, Keio Canc Ctr, Tokyo, Japan
来源：
ANTICANCER RESEARCH | 2015年 / 35卷 / 01期
关键词：
FOXD1; non-small cell lung cancer; microarray; pathway signature; PTEN; GENE-EXPRESSION; PTEN LOSS; SIGNATURES; AKT; METASTASIS; SUPPRESSOR; ERLOTINIB; PROTEINS; SURVIVAL; FOXA2;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Clinical microarray datasets were analyzed to search for new therapeutic targets and prognostic markers of non-small cell lung cancer (NSCLC). Materials and Methods: Microarray datasets from 90 lung cancer specimens, were analyzed with focus on the FOXD1 gene. Levels of FOXDI mRNA were assessed in lung cancer cell lines and these levels were correlated with survival. Results: FOXD1-knockdown led to suppression of cell proliferation. Moreover, patients with high FOXDI expression survived for a significantly shorter time than those with low FOXDI expression. Conclusion: The expression status of FOXD1 is a novel prognostic factor and may lead to new treatment strategies for NSCLC.
引用
收藏
页码：261 / 268
页数：8
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