Prenatal Exposure to Alcohol Alters TLR4 Mediated Signaling in the Prefrontal Cortex in Rats

被引：1
作者：
Airapetov, M. I. [1 ,2 ]
Eresko, S. O. [1 ,3 ]
Bychkov, E. R. [1 ]
Lebedev, A. A. [1 ]
Shabanov, P. D. [1 ,4 ]
机构：
[1] Inst Expt Med, Ul Akad Pavlova 12, St Petersburg 197376, Russia
[2] St Petersburg State Pediat Med Univ, Ul Litovskaya 2, St Petersburg 194100, Russia
[3] St Petersburg State Chem & Pharmaceut Univ, Ul Prof Popova 14A, St Petersburg 197022, Russia
[4] Kirov Mil Med Acad, Ul Akad Lebedeva 6, St Petersburg 194044, Russia
来源：
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY | 2022年 / 16卷 / 02期
关键词：
rats; pregnancy; alcohol; brain; neuroinflammation; MICROGLIA;
D O I：
10.1134/S1990750822020032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Prenatal alcohol exposure (PAE) can lead to developmental disorders of the central nervous system (CNS) and mental retardation. Toll-like receptor (TLR) 4 plays an important role in the development of defects in the nervous system caused by PAE. However, how PAE affects the TLR4 response in the brain remains unclear. Using the model of semi-forced alcoholization of pregnant rats, we have investigated TLR4-mediated signaling on the 30th day of postnatal development in their offspring. Rats exposed to PAE showed a higher expression of proinflammatory cytokines in the prefrontal cortex, but TLR4-mediated signaling in response to lipopolysaccharide (LPS) was weakened. These data suggest that PAE can lead to neuroinflammation and suppression of the TLR4-mediated response to LPS in the prefrontal cortex of young rats. Since innate immunity plays an important role in brain development, PAE-induced suppression of the TLR4-mediated response may be one of the mechanisms for the development of CNS pathology.
引用
收藏
页码：134 / 139
页数：6
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