The Role of Fungus in Chronic Rhinosinusitis

被引：17

作者：

Orlandi, Richard R. ^{[1
]}

Marple, Bradley F. ^{[2
]}

机构：

[1] Univ Utah, Div Otolaryngol Head & Neck Surg, Salt Lake City, UT 84132 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75390 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2010年 / 43卷 / 03期

关键词：

Chronic rhinosinusitis; Fungus; Alternaria; Amphotericin B; Etiology; Pathogenesis; TOPICAL AMPHOTERICIN-B; NASAL POLYPS; DOUBLE-BLIND; ANTIFUNGAL TREATMENT; IRRIGATION; ORGANISMS; MARKERS; PROTEIN; CELLS; TRIAL;

D O I：

10.1016/j.otc.2010.02.011

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Fungus has been cited as an etiologic factor (the etiologic factor?) in chronic rhinosinusitis (CRS), and a vigorous debate has ensued. Initial reports of in vitro observations promoted fungus as a potential origin of CRS, yet subsequent clinical trials of topical and systemic antifungal treatments have failed to demonstrate meaningful efficacy. More recent laboratory work has cast significant doubt on the universality of the fungal hypothesis by failing to replicate one of its basic science underpinnings. Combined with clinical data about antifungal therapy's ineffectiveness, these findings appear to tip the scales against fungus as the universal etiology of CRS.

引用

页码：531 / +

页数：8