Proteomic Characterization of High-Density Lipoprotein Particles from Non-Diabetic Hemodialysis Patients
被引:12
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Florens, Nans
[1
,2
]
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Calzada, Catherine
[1
]
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Delolme, Frederic
[3
]
Page, Adeline
论文数: 0引用数: 0
h-index: 0
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Univ Claude Bernard Lyon 1, ENS Lyon, Prot Sci Facil, SFR BioSci,CNRS,UMS3444,Inserm,US8, F-69007 Lyon, FranceUniv Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CarMeN,INSERM,U1060,U1397,INRA, F-69621 Villeurbanne, France
Page, Adeline
[3
]
Guebre Egziabher, Fitsum
论文数: 0引用数: 0
h-index: 0
机构:
Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CarMeN,INSERM,U1060,U1397,INRA, F-69621 Villeurbanne, France
Hosp Civils Lyon, Hop E Herriot, Serv Nephrol Hypertens Hemodialyse, F-69003 Lyon, FranceUniv Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CarMeN,INSERM,U1060,U1397,INRA, F-69621 Villeurbanne, France
Guebre Egziabher, Fitsum
[1
,2
]
Juillard, Laurent
论文数: 0引用数: 0
h-index: 0
机构:
Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CarMeN,INSERM,U1060,U1397,INRA, F-69621 Villeurbanne, France
Hosp Civils Lyon, Hop E Herriot, Serv Nephrol Hypertens Hemodialyse, F-69003 Lyon, FranceUniv Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CarMeN,INSERM,U1060,U1397,INRA, F-69621 Villeurbanne, France
Juillard, Laurent
[1
,2
]
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Soulage, Christophe O.
[1
]
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[1] Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CarMeN,INSERM,U1060,U1397,INRA, F-69621 Villeurbanne, France
[2] Hosp Civils Lyon, Hop E Herriot, Serv Nephrol Hypertens Hemodialyse, F-69003 Lyon, France
[3] Univ Claude Bernard Lyon 1, ENS Lyon, Prot Sci Facil, SFR BioSci,CNRS,UMS3444,Inserm,US8, F-69007 Lyon, France
Chronic kidney disease is associated with an increased cardiovascular risk, and altered biological properties of high-density lipoproteins (HDL) may play a role in these events. This study aimed to describe the HDL proteome from non-diabetic hemodialysis patients and identify potential pathways affected by the dysregulated expression of HDL proteins. HDL were sampled from nine non-diabetic hemodialysis (HD) and eight control patients. Samples were analyzed using a nano-RSLC coupled with a Q-Orbitrap. Data were processed by database searching using SequestHT against a human Swissprot database and quantified with a label-free quantification approach. Proteins that were in at least five of the eight control and six of the nine HD patients were analyzed. Analysis was based on pairwise ratios and the ANOVA hypothesis test. Among 522 potential proteins, 326 proteins were identified to be in the HDL proteome from HD and control patients, among which 10 were significantly upregulated and nine downregulated in HD patients compared to the control patients (p < 0.05). Up and downregulated proteins were involved in lipid metabolism, hemostasis, wound healing, oxidative stress, and apoptosis pathways. This difference in composition could partly explain HDL dysfunction in the chronic kidney disease (CKD) population and participate in the higher cardiovascular risk observed in this population.
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Great Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
UCL, Inst Child Hlth, Vasc Physiol Unit, London, EnglandGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Shroff, Rukshana
Speer, Thimoteus
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saarland, Med Ctr, Dept Internal Med Nephrol & Hypertens, Homburg, Saar, GermanyGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Speer, Thimoteus
Colin, Sophie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, French Inst Hlth & Med Res, Joint Res Unit 1011, European Genom Inst Diabet,Lille Pasteur Inst, Lille, FranceGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Colin, Sophie
Charakida, Marietta
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Child Hlth, Vasc Physiol Unit, London, EnglandGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Charakida, Marietta
Zewinger, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saarland, Med Ctr, Dept Internal Med Nephrol & Hypertens, Homburg, Saar, GermanyGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Zewinger, Stephen
Staels, Bart
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, French Inst Hlth & Med Res, Joint Res Unit 1011, European Genom Inst Diabet,Lille Pasteur Inst, Lille, FranceGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Staels, Bart
Chinetti-Gbaguidi, Giulia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, French Inst Hlth & Med Res, Joint Res Unit 1011, European Genom Inst Diabet,Lille Pasteur Inst, Lille, FranceGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Chinetti-Gbaguidi, Giulia
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Hettrich, Inga
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Rohrer, Lucia
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O'Neill, Francis
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McLoughlin, Eve
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Long, David
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Shanahan, Catherine M.
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Landmesser, Ulf
Fliser, Danilo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saarland, Med Ctr, Dept Internal Med Nephrol & Hypertens, Homburg, Saar, GermanyGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Fliser, Danilo
Deanfield, John E.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Child Hlth, Vasc Physiol Unit, London, EnglandGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Deanfield, John E.
[J].
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,
2014,
25
(11):
: 2658
-
2668
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, Sweden
Antwerp Univ Hosp, Dept Nephrol, Antwerp, Belgium
Univ Antwerp, Antwerp, BelgiumKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Van Craenenbroeck, Amaryllis H.
Bragfors-Helin, Ann-Christin
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Bragfors-Helin, Ann-Christin
Qureshi, Abdul Rashid
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Qureshi, Abdul Rashid
Lindholm, Bengt
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Lindholm, Bengt
Sjoberg, Bodil
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Sjoberg, Bodil
Anderstam, Bjorn
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Anderstam, Bjorn
Heimburger, Olof
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Heimburger, Olof
Stenvinkel, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Stenvinkel, Peter
Barany, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
机构:
Great Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
UCL, Inst Child Hlth, Vasc Physiol Unit, London, EnglandGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Shroff, Rukshana
Speer, Thimoteus
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saarland, Med Ctr, Dept Internal Med Nephrol & Hypertens, Homburg, Saar, GermanyGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Speer, Thimoteus
Colin, Sophie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, French Inst Hlth & Med Res, Joint Res Unit 1011, European Genom Inst Diabet,Lille Pasteur Inst, Lille, FranceGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Colin, Sophie
Charakida, Marietta
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Child Hlth, Vasc Physiol Unit, London, EnglandGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Charakida, Marietta
Zewinger, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saarland, Med Ctr, Dept Internal Med Nephrol & Hypertens, Homburg, Saar, GermanyGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Zewinger, Stephen
Staels, Bart
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, French Inst Hlth & Med Res, Joint Res Unit 1011, European Genom Inst Diabet,Lille Pasteur Inst, Lille, FranceGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Staels, Bart
Chinetti-Gbaguidi, Giulia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille 2, French Inst Hlth & Med Res, Joint Res Unit 1011, European Genom Inst Diabet,Lille Pasteur Inst, Lille, FranceGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Chinetti-Gbaguidi, Giulia
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Hettrich, Inga
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Rohrer, Lucia
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机构:
O'Neill, Francis
论文数: 引用数:
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机构:
McLoughlin, Eve
论文数: 引用数:
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机构:
Long, David
论文数: 引用数:
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机构:
Shanahan, Catherine M.
论文数: 引用数:
h-index:
机构:
Landmesser, Ulf
Fliser, Danilo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saarland, Med Ctr, Dept Internal Med Nephrol & Hypertens, Homburg, Saar, GermanyGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Fliser, Danilo
Deanfield, John E.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, Inst Child Hlth, Vasc Physiol Unit, London, EnglandGreat Ormond St Hosp Sick Children, Nephrol Unit, London WC1N 3JH, England
Deanfield, John E.
[J].
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,
2014,
25
(11):
: 2658
-
2668
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, Sweden
Antwerp Univ Hosp, Dept Nephrol, Antwerp, Belgium
Univ Antwerp, Antwerp, BelgiumKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Van Craenenbroeck, Amaryllis H.
Bragfors-Helin, Ann-Christin
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Bragfors-Helin, Ann-Christin
Qureshi, Abdul Rashid
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Qureshi, Abdul Rashid
Lindholm, Bengt
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Lindholm, Bengt
Sjoberg, Bodil
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Sjoberg, Bodil
Anderstam, Bjorn
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Anderstam, Bjorn
Heimburger, Olof
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Heimburger, Olof
Stenvinkel, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Stenvinkel, Peter
Barany, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden