Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection

被引：25
作者：
Ahmad, Faran [1 ]
Ahmed, Arslan [1 ]
Rajendraprasad, Sanu S. [1 ]
Loranger, Austin [1 ]
Gupta, Sonia [1 ]
Velagapudi, Manasa [1 ]
Vivekanandan, Renuga [1 ,2 ,3 ]
Nahas, Joseph A. [1 ]
Plambeck, Robert [1 ]
Moore, Douglas [1 ]
机构：
[1] Creighton Univ Med Ctr Bergan Mercy, 7500 Mercy Rd, Omaha, NE 68124 USA
[2] Creighton Univ, Sch Med, Omaha, NE 68124 USA
[3] Dr CC & Mabel L Criss Hlth Sci Complex 2, Omaha, NE 68178 USA
来源：
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2021年 / 108卷
关键词：
SARS-CoV-2; infection; COVID-19; Multisystem inflammatory syndrome in adults (MIS-A);
D O I：
10.1016/j.ijid.2021.05.050
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Multisystem inflammatory syndrome in adults (MIS-A) came to attention back in June 2020, when the United States Center for Disease Control and Prevention (CDC) received initial reports regarding patients who had presented delayed and multisystem involvement of the disease, with clinical course resembling multisystem inflammatory syndrome in children (MIS-C). This study introduces a case of MIS-A, where the patient presented 3 weeks after initial COVID-19 exposure. His clinical course was consistent with the working definition of MIS-A as specified by the CDC. Aggressive supportive care in the intensive care unit, utilization of advanced heart failure devices, and immunomodulatory therapeutics (high-dose steroids, anakinra, intravenous immunoglobulin) led to clinical recovery. Management of MIS-A is a topic of ongoing research and needs more studies to elaborate on treatment modalities and clinical predictors. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).
引用
收藏
页码：209 / 211
页数：3
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共 13 条
  • [1] Multiple system inflammatory syndrome associated with SARS-CoV-2 infection in an adult and an adolescent
    Bastug, Aliye
    Aslaner, Halide
    Aybar Bilir, Yesim
    Kemirtlek, Nizamettin
    Gursoy, Fahriye Melis
    Bastug, Serdal
    Bodur, Hurrem
    [J]. RHEUMATOLOGY INTERNATIONAL, 2021, 41 (05) : 993 - 1008
  • [2] Cardiogenic Shock and Hyperinflammatory Syndrome in Young Males With COVID-19
    Chau, Vinh Q.
    Giustino, Gennaro
    Mahmood, Kiran
    Oliveros, Estefania
    Neibart, Eric
    Oloomi, Mehdi
    Moss, Noah
    Mitter, Sumeet S.
    Contreras, Johanna P.
    Croft, Lori
    Serrao, Gregory
    Parikh, Aditya G.
    Lala, Anuradha
    Trivieri, Maria G.
    LaRocca, Gina
    Anyanwu, Anelechi
    Pinney, Sean P.
    Mancini, Donna M.
    [J]. CIRCULATION-HEART FAILURE, 2020, 13 (10) : E007485
  • [3] Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19
    Feldstein, Leora R.
    Tenforde, Mark W.
    Friedman, Kevin G.
    Newhams, Margaret
    Rose, Erica Billig
    Dapul, Heda
    Soma, Vijaya L.
    Maddux, Aline B.
    Mourani, Peter M.
    Bowens, Cindy
    Maamari, Mia
    Hall, Mark W.
    Riggs, Becky J.
    Giuliano, John S., Jr.
    Singh, Aalok R.
    Li, Simon
    Kong, Michele
    Schuster, Jennifer E.
    McLaughlin, Gwenn E.
    Schwartz, Stephanie P.
    Walker, Tracie C.
    Loftis, Laura L.
    Hobbs, Charlotte V.
    Halasa, Natasha B.
    Doymaz, Sule
    Babbitt, Christopher J.
    Hume, Janet R.
    Gertz, Shira J.
    Irby, Katherine
    Clouser, Katharine N.
    Cvijanovich, Natalie Z.
    Bradford, Tamara T.
    Smith, Lincoln S.
    Heidemann, Sabrina M.
    Zackai, Sheemon P.
    Wellnitz, Kari
    Nofziger, Ryan A.
    Horwitz, Steven M.
    Carroll, Ryan W.
    Rowan, Courtney M.
    Tarquinio, Keiko M.
    Mack, Elizabeth H.
    Fitzgerald, Julie C.
    Coates, Bria M.
    Jackson, Ashley M.
    Young, Cameron C.
    Son, Mary Beth F.
    Patel, Manish M.
    Newburger, Jane W.
    Randolph, Adrienne G.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (11): : 1074 - 1087
  • [4] Multisystem Inflammatory Syndrome in US Children and Adolescents
    Feldstein, Leora R.
    Rose, Erica B.
    Horwitz, Steven M.
    Collins, Jennifer P.
    Newhams, Margaret M.
    Son, Mary Beth F.
    Newburger, Jane W.
    Kleinman, Lawrence C.
    Heidemann, Sabrina M.
    Martin, Amarilis A.
    Singh, Aalok R.
    Li, Simon
    Tarquinio, Keiko M.
    Jaggi, Preeti
    Oster, Matthew E.
    Zackai, Sheemon P.
    Gillen, Jennifer
    Ratner, Adam J.
    Walsh, Rowan F.
    Fitzgerald, Julie C.
    Keenaghan, Michael A.
    Alharash, Hussam
    Doymaz, Sule
    Clouser, Katharine N.
    Giuliano, John S.
    Gupta, Anjali
    Parker, Robert M.
    Maddux, Aline B.
    Havalad, Vinod
    Ramsingh, Stacy
    Bukulmez, Hulya
    Bradford, Tamara T.
    Smith, Lincoln S.
    Tenforde, Mark W.
    Carroll, Christopher L.
    Riggs, Becky J.
    Gertz, Shira J.
    Daube, Ariel
    Lansell, Amanda
    Coronado Munoz, Alvaro
    Hobbs, Charlotte V.
    Marohn, Kimberly L.
    Halasa, Natasha B.
    Patel, Manish M.
    Randolph, Adrienne G.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) : 334 - 346
  • [5] Coronavirus Disease 2019 Acute Myocarditis and Multisystem Inflammatory Syndrome in Adult Intensive and Cardiac Care Units
    Hekimian, Guillaume
    Kerneis, Mathieu
    Zeitouni, Michel
    Cohen-Aubart, Fleur
    Chommeloux, Juliette
    Brechot, Nicolas
    Mathian, Alexis
    Lebreton, Guillaume
    Schmidt, Matthieu
    Hie, Miguel
    Silvain, Johanne
    de Chambrun, Marc Pineton
    Haroche, Julien
    Burrel, Sonia
    Marot, Stephane
    Luyt, Charles-Edouard
    Leprince, Pascal
    Amoura, Zahir
    Montalescot, Gilles
    Redheuil, Alban
    Combes, Alain
    [J]. CHEST, 2021, 159 (02) : 657 - 662
  • [6] American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 1
    Henderson, Lauren A.
    Canna, Scott W.
    Friedman, Kevin G.
    Gorelik, Mark
    Lapidus, Sivia K.
    Bassiri, Hamid
    Behrens, Edward M.
    Ferris, Anne
    Kernan, Kate F.
    Schulert, Grant S.
    Seo, Philip
    F. Son, Mary Beth
    Tremoulet, Adriana H.
    Yeung, Rae S. M.
    Mudano, Amy S.
    Turner, Amy S.
    Karp, David R.
    Mehta, Jay J.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2020, 72 (11) : 1791 - 1805
  • [7] COVID-19 and multisystem inflammatory syndrome in children and adolescents
    Jiang, Li
    Tang, Kun
    Levin, Mike
    Irfan, Omar
    Morris, Shaun K.
    Wilson, Karen
    Klein, Jonathan D.
    Bhutta, Zulfiqar A.
    [J]. LANCET INFECTIOUS DISEASES, 2020, 20 (11) : E276 - E288
  • [8] Role of intravenous immunoglobulin in the treatment of Kawasaki disease
    Lo, Mindy S.
    Newburger, Jane W.
    [J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2018, 21 (01) : 64 - 69
  • [9] Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases
    Magro, Cynthia
    Mulvey, J. Justin
    Berlin, David
    Nuovo, Gerard
    Salvatore, Steven
    Harp, Joanna
    Baxter-Stoltzfus, Amelia
    Laurence, Jeffrey
    [J]. TRANSLATIONAL RESEARCH, 2020, 220 : 1 - 13
  • [10] Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome
    Mehta, Puja
    Cron, Randy Q.
    Hartwell, James
    Manson, Jessica J.
    Tattersall, Rachel S.
    [J]. LANCET RHEUMATOLOGY, 2020, 2 (06) : E358 - E367
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