共 45 条
Silencing of the chemokine CXC receptor 4 (CXCR4) hampers cancer progression and increases cisplatin (DDP)-sensitivity in clear cell renal cell carcinoma (ccRCC)
被引:5
作者:

Wang, Wenguang
论文数: 0 引用数: 0
h-index: 0
机构:
Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China

Gan, Zhilu
论文数: 0 引用数: 0
h-index: 0
机构:
Third Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Urol, Urumqi, Peoples R China Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China

Liu, Qiang
论文数: 0 引用数: 0
h-index: 0
机构:
Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China

Yan, Shenshen
论文数: 0 引用数: 0
h-index: 0
机构:
Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China

Mulati, Rexiti
论文数: 0 引用数: 0
h-index: 0
机构:
Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China

Wang, Yujie
论文数: 0 引用数: 0
h-index: 0
机构:
Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China
机构:
[1] Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Liyushan South Rd 137, Urumqi 830054, Xinjiang, Peoples R China
[2] Third Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Urol, Urumqi, Peoples R China
关键词:
Clear cell renal cell carcinoma;
chemokine receptor 4;
cisplatin-sensitivity;
cancer biology;
RESISTANCE;
PROMOTES;
PROLIFERATION;
EXPRESSION;
MIGRATION;
INVASION;
CHEMORESISTANCE;
IMMUNOTHERAPY;
ANTAGONIST;
SURVIVAL;
D O I:
10.1080/21655979.2021.1943112
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Aberrant expression of the chemokine CXC receptor 4 (CXCR4) is closely associated with cancer progression and drug-resistance in multiple cancers, and we first investigated the role of CXCR4 in regulating cancer pathogenesis and cisplatin (DDP)-resistance in clear cell renal cell carcinoma (ccRCC) in the present study. Here, we identified that CXCR4 acted as an oncogene to promote cancer progression and genetically silencing of CXCR4 increased cisplatin (DDP)-sensitivity in ccRCC in vitro and in vivo. Functionally, analysis from the clinical and cellular data indicated that CXCR4 was significantly upregulated in ccRCC tissues and cells, compared to their normal counterparts. Next, the loss-of-function experiments validated that knock-down of CXCR4 suppressed cell proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) in ccRCC cells, while CXCR4 overexpression had opposite effects on the above cellular functions. Consistently, the xenograft tumor-bearing mice models were established, and the results supported that knock-down of CXCR4 inhibited tumor growth and the expression levels of Ki67 protein in vivo. In addition, the ccRCC cells were exposed to DDP treatment, and we surprisingly found that upregulation of CXCR4 increased DDP-resistance in ccRCC cells, and conversely, CXCR4 ablation sensitized ccRCC cells to DDP stimulation. Taken together, we concluded that CXCR4 ablation hindered cancer progression and enhanced DDP-sensitivity in ccRCC, and the present study identified a novel therapeutic biomarker for ccRCC.
引用
收藏
页码:2957 / 2969
页数:13
相关论文
共 45 条
[1]
Role of Biomarkers in Prediction of Response to Therapeutics in Metastatic Renal-Cell Carcinoma
[J].
Adashek, Jacob J.
;
Salgia, Meghan M.
;
Posadas, Edwin M.
;
Figlin, Robert A.
;
Gong, Jun
.
CLINICAL GENITOURINARY CANCER,
2019, 17 (03)
:E454-E460

Adashek, Jacob J.
论文数: 0 引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA USA Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA USA

Salgia, Meghan M.
论文数: 0 引用数: 0
h-index: 0
机构:
City Of Hope, Comprehens Canc Ctr, Dept Med Oncol & Expt Therapeut, Duarte, CA USA Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA USA

Posadas, Edwin M.
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, 8700 Beverly Blvd,AC 1042B, Los Angeles, CA 90048 USA Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA USA

Figlin, Robert A.
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, 8700 Beverly Blvd,AC 1042B, Los Angeles, CA 90048 USA Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA USA

Gong, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, 8700 Beverly Blvd,AC 1042B, Los Angeles, CA 90048 USA Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA USA
[2]
Current and emerging therapies for first-line treatment of metastatic clear cell renal cell carcinoma
[J].
Atkins, Michael B.
;
Tannir, Nizar M.
.
CANCER TREATMENT REVIEWS,
2018, 70
:127-137

Atkins, Michael B.
论文数: 0 引用数: 0
h-index: 0
机构:
Georgetown Lombardi Comprehens Canc Ctr, 3970 Reservoir Rd NW,Res Bldg,Room E501, Washington, DC 20057 USA Georgetown Lombardi Comprehens Canc Ctr, 3970 Reservoir Rd NW,Res Bldg,Room E501, Washington, DC 20057 USA

Tannir, Nizar M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA Georgetown Lombardi Comprehens Canc Ctr, 3970 Reservoir Rd NW,Res Bldg,Room E501, Washington, DC 20057 USA
[3]
First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study
[J].
Balar, Arjun V.
;
Castellano, Daniel
;
O'Donnell, Peter H.
;
Grivas, Petros
;
Vuky, Jacqueline
;
Powles, Thomas
;
Plimack, Elizabeth R.
;
Hahn, Noah M.
;
de Wit, Ronald
;
Pang, Lei
;
Savage, Mary J.
;
Perini, Rodolfo F.
;
Keefe, Stephen M.
;
Bajorin, Dean
;
Bellmunt, Joaquim
.
LANCET ONCOLOGY,
2017, 18 (11)
:1483-1492

Balar, Arjun V.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Castellano, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Univ 12 Octubre CiberOnc, Madrid, Spain NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

O'Donnell, Peter H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Med Ctr, Chicago, IL 60637 USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Grivas, Petros
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44106 USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Vuky, Jacqueline
论文数: 0 引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Portland, OR 97201 USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Powles, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, London, England NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Plimack, Elizabeth R.
论文数: 0 引用数: 0
h-index: 0
机构:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Hahn, Noah M.
论文数: 0 引用数: 0
h-index: 0
机构:
Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

de Wit, Ronald
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus MC Canc Inst, Rotterdam, Netherlands NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Pang, Lei
论文数: 0 引用数: 0
h-index: 0
机构:
Merck & Co Inc, Kenilworth, NJ USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Savage, Mary J.
论文数: 0 引用数: 0
h-index: 0
机构:
Merck & Co Inc, Kenilworth, NJ USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Perini, Rodolfo F.
论文数: 0 引用数: 0
h-index: 0
机构:
Merck & Co Inc, Kenilworth, NJ USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Keefe, Stephen M.
论文数: 0 引用数: 0
h-index: 0
机构:
Merck & Co Inc, Kenilworth, NJ USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

Bajorin, Dean
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY 10016 USA

论文数: 引用数:
h-index:
机构:
[4]
Treatment of renal cell carcinoma: Current status and future directions
[J].
Barata, Pedro C.
;
Rini, Brian I.
.
CA-A CANCER JOURNAL FOR CLINICIANS,
2017, 67 (06)
:507-524

Barata, Pedro C.
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH 44106 USA Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH 44106 USA

Rini, Brian I.
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin, Lerner Coll Med, Med, Cleveland, OH 44106 USA
Cleveland Clin, Taussig Canc Inst, Genitourinary Program, Glickman Urol & Kidney Inst,Dept Hematol & Oncol, Cleveland, OH 44106 USA Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH 44106 USA
[5]
Cabozantinib in Combination with Immunotherapy for Advanced Renal Cell Carcinoma and Urothelial Carcinoma: Rationale and Clinical Evidence
[J].
Bergerot, Paulo
;
Lamb, Peter
;
Wang, Evelyn
;
Pal, Sumanta K.
.
MOLECULAR CANCER THERAPEUTICS,
2019, 18 (12)
:2185-2193

Bergerot, Paulo
论文数: 0 引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA

Lamb, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Exelixis Inc, Alameda, CA USA City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA

Wang, Evelyn
论文数: 0 引用数: 0
h-index: 0
机构:
Exelixis Inc, Alameda, CA USA City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA

Pal, Sumanta K.
论文数: 0 引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA
[6]
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
[J].
Berlato, Chiara
;
Khan, Moddasar N.
;
Schioppa, Tiziana
;
Thompson, Richard
;
Maniati, Eleni
;
Montfort, Anne
;
Jangani, Maryam
;
Canosa, Monica
;
Kulbe, Hagen
;
Hagemann, Urs B.
;
Duncan, Alexander R.
;
Fletcher, Laura
;
Wilkinson, Robert W.
;
Powles, Thomas
;
Quezada, Sergio A.
;
Balkwill, Frances R.
.
JOURNAL OF CLINICAL INVESTIGATION,
2017, 127 (03)
:801-813

Berlato, Chiara
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Khan, Moddasar N.
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Schioppa, Tiziana
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England
Univ Brescia, Dept Mol & Translat Med, Brescia, Italy Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Montfort, Anne
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Jangani, Maryam
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Canosa, Monica
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Kulbe, Hagen
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England
Charite, Dept Gynecol, Berlin, Germany Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Hagemann, Urs B.
论文数: 0 引用数: 0
h-index: 0
机构:
Affitech Res AS, Oslo, Norway Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Duncan, Alexander R.
论文数: 0 引用数: 0
h-index: 0
机构:
Affitech Res AS, Oslo, Norway Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Fletcher, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res Technol Ltd, London, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Wilkinson, Robert W.
论文数: 0 引用数: 0
h-index: 0
机构:
MedImmune Ltd, Cambridge, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Powles, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Quezada, Sergio A.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, UCL Canc Inst, Dept Res Haematol, Canc Immunol Unit, London, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England

Balkwill, Frances R.
论文数: 0 引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England Queen Mary Univ London, Barts Canc Inst, Charterhouse Sq, London EC1M 6BQ, England
[7]
Investigating the Chemokine Receptor 4 as Potential Theranostic Target in Adrenocortical Cancer Patients
[J].
Bluemel, Christina
;
Hahner, Stefanie
;
Heinze, Britta
;
Fassnacht, Martin
;
Kroiss, Matthias
;
Bley, Thorsten A.
;
Wester, Hans-Juergen
;
Kropf, Saskia
;
Lapa, Constantin
;
Schirbel, Andreas
;
Buck, Andreas K.
;
Herrmann, Ken
.
CLINICAL NUCLEAR MEDICINE,
2017, 42 (01)
:E29-E34

Bluemel, Christina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Hahner, Stefanie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Div Endocrinol, Dept Internal Med 1, Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Heinze, Britta
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Div Endocrinol, Dept Internal Med 1, Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Fassnacht, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Div Endocrinol, Dept Internal Med 1, Wurzburg, Germany
Univ Hosp Wurzburg, Ctr Comprehens Canc, Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Kroiss, Matthias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Ctr Comprehens Canc, Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Bley, Thorsten A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Dept Radiol, Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Wester, Hans-Juergen
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Pharmaceut Radiochem, Munich, Germany
Scintomics GmbH, Furstenfeldbruck, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Kropf, Saskia
论文数: 0 引用数: 0
h-index: 0
机构:
Scintomics GmbH, Furstenfeldbruck, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Lapa, Constantin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Schirbel, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Buck, Andreas K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany

Herrmann, Ken
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany
Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA Univ Hosp Wurzburg, Dept Nucl Med, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany
[8]
CXCR4 WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplant MYD88L265P-directed survival signalling in Waldenstrom macroglobulinaemia cells
[J].
Cao, Yang
;
Hunter, Zachary R.
;
Liu, Xia
;
Xu, Lian
;
Yang, Guang
;
Chen, Jie
;
Tsakmaklis, Nickolas
;
Kanan, Sandra
;
Castillo, Jorge J.
;
Treon, Steven P.
.
BRITISH JOURNAL OF HAEMATOLOGY,
2015, 168 (05)
:701-707

Cao, Yang
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Hunter, Zachary R.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA
Boston Univ, Sch Med, Dept Pathol, Boston, MA 02118 USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Liu, Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Xu, Lian
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Yang, Guang
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Chen, Jie
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Tsakmaklis, Nickolas
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Kanan, Sandra
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Castillo, Jorge J.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA

Treon, Steven P.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USA Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02115 USA
[9]
High CXCR4 Expression Correlates with Sunitinib Poor Response in Metastatic Renal Cancer
[J].
D'Alterio, C.
;
Portella, L.
;
Ottaiano, A.
;
Rizzo, M.
;
Carteni, G.
;
Pignata, S.
;
Facchini, G.
;
Perdona, S.
;
Di Lorenzo, G.
;
Autorino, R.
;
Franco, R.
;
La Mura, A.
;
Nappi, O.
;
Castello, G.
;
Scala, S.
.
CURRENT CANCER DRUG TARGETS,
2012, 12 (06)
:693-702

D'Alterio, C.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Portella, L.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Ottaiano, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Clin Oncol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Rizzo, M.
论文数: 0 引用数: 0
h-index: 0
机构:
AORN Cardarelli, Dept Clin Oncol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Carteni, G.
论文数: 0 引用数: 0
h-index: 0
机构:
AORN Cardarelli, Dept Clin Oncol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Pignata, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Clin Oncol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Facchini, G.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Clin Oncol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Perdona, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Urol Div, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Di Lorenzo, G.
论文数: 0 引用数: 0
h-index: 0
机构:
AOU Federico II, Clin Oncol Sect, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Autorino, R.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Urol Div, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Franco, R.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Pathol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

La Mura, A.
论文数: 0 引用数: 0
h-index: 0
机构:
AORN Cardarelli, Dept Pathol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Nappi, O.
论文数: 0 引用数: 0
h-index: 0
机构:
AORN Cardarelli, Dept Pathol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Castello, G.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy

Scala, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy Ist Studio & Cura Tumori Pascale, Dept Oncol Immunol, Naples, Italy
[10]
Upregulation of CXC chemokine receptor 4-CXC chemokine ligand 12 axis in invasive breast carcinoma: A potent biomarker predicting lymph node metastasis
[J].
Dayer, Reza
;
Babashah, Sadegh
;
Jamshidi, Shirin
;
Sadeghizadeh, Majid
.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,
2018, 14 (02)
:345-350

Dayer, Reza
论文数: 0 引用数: 0
h-index: 0
机构:
Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, POB 14115-154, Tehran, Iran Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, POB 14115-154, Tehran, Iran

论文数: 引用数:
h-index:
机构:

Jamshidi, Shirin
论文数: 0 引用数: 0
h-index: 0
机构:
Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, POB 14115-154, Tehran, Iran Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, POB 14115-154, Tehran, Iran

Sadeghizadeh, Majid
论文数: 0 引用数: 0
h-index: 0
机构:
Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, POB 14115-154, Tehran, Iran Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, POB 14115-154, Tehran, Iran