Perinatal exposure to lead and cadmium affects anxiety-like behaviour

被引：64

作者：

Leret, ML ^{[1
]}

San Millán, JA ^{[1
]}

Antonio, MT ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Biol Sci, Dept Anim Biol Anim Physiol 2, E-28040 Madrid, Spain

来源：

TOXICOLOGY | 2003年 / 186卷 / 1-2期

关键词：

lead; cadmium; hippocampus; hypothalamus; monoamines; anxiety; plus-maze;

D O I：

10.1016/S0300-483X(02)00728-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study examines the effects of early simultaneous exposure to low level of lead and cadmium on anxiety-like behaviour in the rat, and on monoamine levels in the hypothalamus and hippocampus at weaning and adult animals. Rats were intoxicated with cadmium acetate (10 mg/l) and lead acetate (300 mg/l) in drinking water from the beginning of pregnancy until weaning. Maternal co-exposure to lead and cadmium produced mainly alterations in dopaminergic and serotoninergic systems of hippocampus in both age studied, while noradrenaline content in hypothalamus and hippocampus remained unchanged at 75 days of age. The intoxicated rats showed an increased on indices of anxiety on the elevated plus-maze. These long-term changes in anxiety-like behaviour can be related to dopaminergic and serotoninergic alterations detected in hippocampus. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：125 / 130

页数：6

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