Fast degradable poly(L-lactide-co-ε-caprolactone) microspheres for tissue engineering:: Synthesis, characterization, and degradation behavior

被引:87
作者
Garkhal, Kalpna
Verma, Shalini
Jonnalagadda, S.
Kumar, Neeraj
机构
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Mohali 160062, India
[2] Univ Sci Philadelphia, Coll Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19104 USA
关键词
biodegradable; biopolymers; copolymerization; degradation; degradation behavior; microspheres; polyesters; poly(lactide-co-epsilon-caprolactone); ring opening polymerization;
D O I
10.1002/pola.22031
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Polymeric scaffolds play a crucial role in engineering process of new tissues and effect the cell growth and viability. PLCL copolymers are found to be very useful during cell growth due to their elastic behavior and mechanical strength. Thus, low molecular weight PLCL copolymers of various ratios viz. PLCL(90/10), PLCL(75/25), PLCL(50/50) and PCL were synthesized by ring opening polymerization using stannous octoate as a catalyst. Synthesized polymers were characterized by GPC, H-1-NMR, FTIR and XRD. The thermal properties of the copolymers were studied using TGA and DSC. Microspheres of about 100 mu m diameter were prepared for different copolymers and their in vitro degradation behaviors were studied up to 108 days. It was observed that degradation of PLA content in polymer backbone occurs faster than PCL component which is also indicated by corresponding change in ratios of PLA/PCL, as determined by H-1-NMR. SEM images of microspheres depicted the surface morphology during degradation and suggested the faster degradation for PLCL (50:50). Copolymers of different thermal, mechanical properties and different degradation behaviors can be prepared by adjusting the composition of copolymers. Various synthesized polymers from this work have been tested in our laboratory as polymeric scaffold for soft tissue engineering. (c) 2007 Wiley Periodicals, Inc.
引用
收藏
页码:2755 / 2764
页数:10
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