Susceptibility to subchronic unpredictable stress is related to individual reactivity to threat stimuli in mice

被引:51
作者
Ducottet, C [1 ]
Aubert, A [1 ]
Belzung, C [1 ]
机构
[1] UFR Sci & Tech, Psychobiol Emot EA3248, F-37200 Tours, France
关键词
subchronic stress; cognitive orientation; conditioned task; grooming;
D O I
10.1016/j.bbr.2004.04.020
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
As in many complex behavioral responses, inter-individual variability can be observed in the responses to a chronic mild stress. While some subjects exhibit more resilient behaviours, others appear more susceptible to stress. This study hypothesizes that this variability relies on the individual appraisal of the stressful event. To study this assumption, mice were first subjected to a conditioned task occurring in a circular arena. In this task, a mild air-puff (i.e. stressor) in a given quadrant of the arena was coupled with the presence or the absence of a light in the same quadrant. Half of mice were then submitted to a 15-day subchronic stress consisting in various environmental and social mild stressors randomly applied two or three times a day. At the end of this procedure, the occurrence of depressive-like behaviours in stressed mice was assessed using measures of the stress regime (i.e. physical state, choice test, grooming test). The physical state assessed the physical appearance of mice. The grooming test consisted in measuring the time spent in grooming after mice were sprayed upon with a viscous solution. The choice test consisted in measuring the time spent in an uncomfortable place (i.e. whose floor was covered with damp sawdust) versus a more comfortable one (i.e. with dry sawdust) to evaluate the reactivity to a negative stimulus previously encountered during the subchronic stress. Multiple regression analyses revealed a relationship between attention toward salient stressful stimuli in the conditioned task and susceptibility to the subchronic stress procedure. These results are discussed regarding their relevance for the understanding of aetiologies of depressive illnesses. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:291 / 299
页数:9
相关论文
共 38 条
[1]   The emotional Stroop effect in anxiety disorders - General emotionality or disorder specificity? [J].
Becker, ES ;
Rinck, M ;
Margraf, J ;
Roth, WT .
JOURNAL OF ANXIETY DISORDERS, 2001, 15 (03) :147-159
[2]   Defense changes in stress nonresponsive subordinate males in a visible burrow system [J].
Blanchard, RJ ;
Yudko, E ;
Dulloog, L ;
Blanchard, DC .
PHYSIOLOGY & BEHAVIOR, 2001, 72 (05) :635-642
[3]   SPECIES-SPECIFIC DEFENSE REACTIONS AND AVOIDANCE LEARNING [J].
BOLLES, RC .
PSYCHOLOGICAL REVIEW, 1970, 77 (01) :32-48
[4]   Effect of social defeat in a territorial bird (Parus major) selected for different coping styles [J].
Carere, C ;
Welink, D ;
Drent, PJ ;
Koolhaas, JM ;
Groothuis, TGG .
PHYSIOLOGY & BEHAVIOR, 2001, 73 (03) :427-433
[5]   Stressful animal housing conditions and their potential effect on sympathetic neurotransmission in mice [J].
D'Arbe, M ;
Einstein, R ;
Lavidis, NA .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2002, 282 (05) :R1422-R1428
[6]   Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice [J].
Ducottet, C ;
Belzung, C .
PHYSIOLOGY & BEHAVIOR, 2004, 81 (03) :417-426
[7]   Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice [J].
Ducottet, C ;
Griebel, G ;
Belzung, C .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2003, 27 (04) :625-631
[8]  
DUCOTTET C, 2004, IN PRESS BEHAV BRAIN
[9]   Chronic subordination stress in male tree shrews:: Replacement of testosterone affects behavior and central alpha2-adrenoceptors [J].
Flügge, G ;
Kramer, M ;
Fuchs, E .
PHYSIOLOGY & BEHAVIOR, 2001, 73 (03) :293-300
[10]   Psychosocial stress in tree shrews: Clomipramine counteracts behavioral and endocrine changes [J].
Fuchs, E ;
Kramer, M ;
Hermes, B ;
Netter, P ;
Hiemke, C .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 54 (01) :219-228