Strategies in the Design of Small-Molecule Fluorescent Probes for Peptidases

被引：28
作者：
Chen, Laizhong [1 ]
Li, Jing [1 ]
Du, Lupei [1 ]
Li, Minyong [1 ]
机构：
[1] Shandong Univ, Sch Pharm, Dept Med Chem, Key Lab Chem Biol MOE, Jinan 250012, Shandong, Peoples R China
来源：
MEDICINAL RESEARCH REVIEWS | 2014年 / 34卷 / 06期
关键词：
peptidases; small-molecule fluorescent probes; design strategies; FIBROBLAST ACTIVATION PROTEIN; SAFETY CATCH LINKER; N APN/CD13; SERINE; INHIBITOR; CYSTEINE; 1ST; BINDING; VISUALIZATION; DERIVATIVES;
D O I：
10.1002/med.21316
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are also involved in many pathological conditions, such as cancer, atherosclerosis, arthritis, and neurodegenerative disorders. This review article aims to conduct a wide-ranging survey on the development of small-molecule fluorescent probes for peptidases, as well as to realize the state of the art in the tailor-made probes for diverse types of peptidases. (C) 2014 Wiley Periodicals, Inc.
引用
收藏
页码：1217 / 1241
页数：25
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