Striatal and Extrastriatal Dopamine Release Measured With PET and [18F] Fallypride

被引:94
作者
Slifstein, Mark [1 ,2 ]
Kegeles, Lawrence S. [1 ,2 ]
Xu, Xiaoyan [1 ,2 ]
Thompson, Judy L. [1 ,2 ]
Urban, Nina [1 ,2 ]
Castrillon, John [1 ,2 ]
Hackett, Elizabeth [1 ,2 ]
Bae, S. -A. [1 ,2 ]
Laruelle, Marc [1 ,3 ]
Abi-Dargham, Anissa [1 ,2 ]
机构
[1] Columbia Univ, New York, NY USA
[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[3] GlaxoSmithKline, London, England
关键词
PET; positron emission tomography; amphetamine; dopamine; D2; receptors; schizophrenia; POSITRON-EMISSION-TOMOGRAPHY; AMPHETAMINE-INDUCED DISPLACEMENT; ENDOGENOUS DOPAMINE; RECEPTOR-BINDING; C-11; RACLOPRIDE; FUNCTIONAL SUBDIVISIONS; SEX-DIFFERENCES; HEALTHY HUMANS; IN-VITRO; RADIOTRACER;
D O I
10.1002/syn.20734
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The amphetamine challenge, in which positron emission tomography (PET) or single photon emission computed tomography radioligand binding following administration of amphetamine is compared to baseline values, has been successfully used in a number of brain imaging studies as an indicator of dopaminergic function, particularly in the striatum. [F-18] fallypride is the first PET radioligand that allows measurement of the effects of amphetamine on D2/D3 ligand binding in striatum and extra-striatal brain regions in a single scanning session following amphetamine. We scanned 15 healthy volunteer subjects with [F-18] fallypride at baseline and following amphetamine (0.3 mg/kg) using arterial plasma input-based modeling as well as reference region methods. We found that amphetamine effect was robustly detected in ventral striatum, globus pallidus, and posterior putamen, and with slightly higher variability in other striatal subregions. However, the observed effect sizes in striatum were less than those observed in previous studies in our laboratory using [C-11] raclopride. Robust effect was also detected in limbic extra-striatal regions (hippocampus, amygdala) and substantia nigra, but the signal-to-noise ratio was too low to allow accurate measurement in cortical regions. We conclude that [F-18] fallypride is a suitable ligand for measuring amphetamine effect in striatum and limbic regions, but it is not suitable for measuring the effect in cortical regions and may not provide the most powerful way to measure the effect in striatum. Synapse 64:350-362, 2010. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:350 / 362
页数:13
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