Drugs of the 21st century: telithromycin (HMR 3647) - the first ketolide

被引：92
作者：
Ackermann, G [1 ]
Rodloff, AC [1 ]
机构：
[1] Univ Leipzig, Inst Med Microbiol & Epidemiol Infect Dis, D-04103 Leipzig, Germany
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 03期
关键词：
new antimicrobials; telithromycin; resistance;
D O I：
10.1093/jac/dkg123
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Telithromycin (HMR 3647) is the first ketolide introduced into clinical practice. Ketolides are semisynthetic derivates of erythromycin A that carry novel biological properties on the erythronolide A ring. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. Ketolides do not induce macrolide-lincosamide-streptogramin B (MLSB) resistance and are active against erythromycin resistance methylase gene (erm)-carrying Gram-positive cocci. This review summarizes published data on telithromycin and intends to define the challenge that a new antimicrobial brings to medical practice.
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收藏
页码：497 / 511
页数：15
相关论文
共 104 条
[61]   BACTERIAL-RESISTANCE TO MACROLIDE, LINCOSAMIDE, AND STREPTOGRAMIN ANTIBIOTICS BY TARGET MODIFICATION [J].
LECLERCQ, R ;
COURVALIN, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (07) :1267-1272
[62]   Mechanisms of resistance to macrolides and lincosamides: Nature of the resistance elements and their clinical implications [J].
Leclercq, R .
CLINICAL INFECTIOUS DISEASES, 2002, 34 (04) :482-492
[63]   Activity of the ketolide telithromycin is refractory to erm monomethylation of bacterial rRNA [J].
Liu, MF ;
Douthwaite, S .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1629-1633
[64]   Activities of antimicrobial agents against intracellular pneumococci [J].
Mandell, GL ;
Coleman, EJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2561-2563
[65]   In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against coryneform bacteria [J].
Martínez-Martínez, L ;
Pascual, A ;
Suárez, AI ;
Perea, EJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (12) :3290-3292
[66]  
MATTOES HM, 2001, 41 INT C ANT AG CHEM, P69
[67]  
MCGUIRE JM, 1952, ANTIBIOT CHEMOTHER, V2, P281
[68]   In vitro activity of telithromycin against Spanish Streptococcus pneumoniae isolates with characterized macrolide resistance mechanisms [J].
Morosini, MI ;
Cantón, R ;
Loza, E ;
Negri, MC ;
Galán, JC ;
Almaraz, F ;
Baquero, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (09) :2427-2431
[69]   Oxazolidinones:: a novel class of antibiotics [J].
Müller, M ;
Schimz, KL .
CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 56 (3-4) :280-285
[70]   Bronchopulmonary disposition of the ketolide telithromycin (HMR 3647) [J].
Muller-Serieys, C ;
Soler, P ;
Cantalloube, C ;
Lemaitre, F ;
Gia, HP ;
Brunner, F ;
Andremont, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (11) :3104-3108
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