Drugs of the 21st century: telithromycin (HMR 3647) - the first ketolide

被引：92
作者：
Ackermann, G [1 ]
Rodloff, AC [1 ]
机构：
[1] Univ Leipzig, Inst Med Microbiol & Epidemiol Infect Dis, D-04103 Leipzig, Germany
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 03期
关键词：
new antimicrobials; telithromycin; resistance;
D O I：
10.1093/jac/dkg123
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Telithromycin (HMR 3647) is the first ketolide introduced into clinical practice. Ketolides are semisynthetic derivates of erythromycin A that carry novel biological properties on the erythronolide A ring. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. Ketolides do not induce macrolide-lincosamide-streptogramin B (MLSB) resistance and are active against erythromycin resistance methylase gene (erm)-carrying Gram-positive cocci. This review summarizes published data on telithromycin and intends to define the challenge that a new antimicrobial brings to medical practice.
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收藏
页码：497 / 511
页数：15
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