Drugs of the 21st century: telithromycin (HMR 3647) - the first ketolide

被引：92
作者：
Ackermann, G [1 ]
Rodloff, AC [1 ]
机构：
[1] Univ Leipzig, Inst Med Microbiol & Epidemiol Infect Dis, D-04103 Leipzig, Germany
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 03期
关键词：
new antimicrobials; telithromycin; resistance;
D O I：
10.1093/jac/dkg123
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Telithromycin (HMR 3647) is the first ketolide introduced into clinical practice. Ketolides are semisynthetic derivates of erythromycin A that carry novel biological properties on the erythronolide A ring. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. Ketolides do not induce macrolide-lincosamide-streptogramin B (MLSB) resistance and are active against erythromycin resistance methylase gene (erm)-carrying Gram-positive cocci. This review summarizes published data on telithromycin and intends to define the challenge that a new antimicrobial brings to medical practice.
引用
收藏
页码：497 / 511
页数：15
相关论文
共 104 条
[1]   In vitro activity of telithromycin (HMR 3647) and seven other antimicrobial agents against anaerobic bacteria [J].
Ackermann, G ;
Schaumann, R ;
Pless, B ;
Claros, MC ;
Rodloff, AC .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (01) :115-119
[2]  
AGOURIDAS C, 1998, 4 INT C MACR AZ STRE
[3]   Resistance among Streptococcus pneumoniae:: Implications for drug selection [J].
Appelbaum, PC .
CLINICAL INFECTIOUS DISEASES, 2002, 34 (12) :1613-1620
[4]   Use of ketolides in combination with other drugs to treat experimental toxoplasmosis [J].
Araujo, FG ;
Khan, AA ;
Bryskier, A ;
Remington, JS .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (05) :665-667
[5]  
AUBIER M, 2001, 41 INT C ANT AG CHEM, P450
[6]  
*AVENT PHARM, 2002, FACH KET 400 MG FILM
[7]   The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].
Ban, N ;
Nissen, P ;
Hansen, J ;
Moore, PB ;
Steitz, TA .
SCIENCE, 2000, 289 (5481) :905-920
[8]   Antipneumococcal activities of a ketolide (HMR 3647), a streptogramin (quinupristin-dalfopristin), a macrolide (erythromycin), and a lincosamide (clindamycin) [J].
Barry, AL ;
Fuchs, PC ;
Brown, SD .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (04) :945-946
[9]   Interpretative criteria and duality control parameters for telithromycin disc diffusion susceptibility tests [J].
Barry, AL ;
Fuchs, PC ;
Brown, SD .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (01) :121-125
[10]  
Barry AL, 2001, EUR J CLIN MICROBIOL, V20, P494
12345678910