p53 and MDM2 isoforms in blood from lung cancer patients

被引：2
作者：
Gonzalez-Avila, Georgina
Biol, Javier Delgado
Martinez, Luis M.
Ramos, Carlos
Sommer, Bettina
机构：
[1] Inst Nacl Enfermedades Resp, Dept Enfermedades Cron Degenerat, Lab Matriz Extracelular, Mexico City 14080, DF, Mexico
[2] Inst Nacl Enfermedades Resp, Oncol Serv, Mexico City, DF, Mexico
来源：
EXPERIMENTAL LUNG RESEARCH | 2007年 / 33卷 / 05期
关键词：
lung cancer; MDM2; MDM2 splicing transcripts; oncogene; p53; EXPRESSION; PROTEIN; OVEREXPRESSION; CARCINOGENESIS; CARCINOMA; ONCOGENES; NETWORK; PATHWAY; ABILITY;
D O I：
10.1080/01902140701481112
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The present study was designed to detect changes in p53 and MDM2 protein expression patterns in plasma from lung cancer patients. The largest p53 protein expression was observed in adenocarcinoma patients; however, mutant p53 was not increased in any cancer sample. A significant increase in the 57-kDa MDM2 isoform was observed in adenocarcinoma patients with low protein expression of the 90-kDa isoform. Our findings suggest that p53 accumulation could be due to a decrease in full-length MDM2 isoform together with an increase of the 57-kDa MDM2 isoform that was unable to stimulate p53 degradation.
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页码：245 / 258
页数：14
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