Gut Microbiota Shifting in Irritable Bowel Syndrome: The Mysterious Role of Blastocystis sp.

被引：6

作者：

Olyaiee, Alireza ^{[1
]}

Sadeghi, Amir ^{[2
]}

Yadegar, Abbas ^{[3
]}

Mirsamadi, Elnaz Sadat ^{[4
]}

Mirjalali, Hamed ^{[3
]}

机构：

[1] IslamicAzad Univ, Dept Biol, Sci & Res Branch, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Foodborne & Waterborne Dis Res Ctr, Tehran, Iran

[4] Islamic Azad Univ, Fac Med, Dept Microbiol, Tehran Med Sci, Tehran, Iran

来源：

FRONTIERS IN MEDICINE | 2022年 / 9卷

关键词：

irritable bowel syndrome; gut microbiota; Blastocystis sp; dysbiosis; post-infectious-IBS; DIENTAMOEBA-FRAGILIS; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; MOLECULAR ANALYSIS; BARRIER FUNCTION; CELL-ACTIVATION; RECEPTOR; INFECTION; PREVALENCE; SUBTYPES;

D O I：

10.3389/fmed.2022.890127

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Irritable bowel syndrome (IBS) is a chronic disorder, which its causative agent is not completely clear; however, the interaction between microorganisms and gastrointestinal (GI) epithelial cells plays a critical role in the development of IBS and presenting symptoms. During recent decades, many studies have highlighted the high prevalence of Blastocystis sp. in patients with IBS and suggested a probable role for this protist in this disease. Recent studies have documented changes in the gut microbiota composition in patients with IBS regarding the presence of Blastocystis sp., but it is not clear that either disturbance of the gut during GI disorders is a favorable condition for Blastocystis sp. colonization or the presence of this protist may lead to alteration in the gut microbiota in IBS patients. In this review, we comprehensively gather and discuss scientific findings covering the role of Blastocystis sp. in IBS via gut microbiota shifting.

引用

页数：11

共 113 条

[1] The neglected role of Blastocystis sp. and Giardia lamblia in development of irritable bowel syndrome: A systematic review and meta-analysis [J].

Abedi, Seyed Hasan ;

Fazlzadeh, Aylar ;

Mollalo, Abolfazl ;

Sartip, Behnam ;

Mahjour, Sanaz ;

Bahadory, Saeed ;

Taghipour, Ali ;

Rostami, Ali .

MICROBIAL PATHOGENESIS, 2022, 162

[2]

Ali S, 2017, CUREUS J MED SCIENCE, V9, DOI 10.7759/cureus.1992

[3] Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling [J].

Anitha, Mallappa ;

Vijay-Kumar, Matam ;

Sitaraman, Shanthi V. ;

Gewirtz, Andrew T. ;

Srinivasan, Shanthi .

GASTROENTEROLOGY, 2012, 143 (04) :1006-+

[4]

[Anonymous], 2002, J. Gastroenterol. Hepatol

[5] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[6] Blastocystis and Clostridioides difficile: Evidence for a Synergistic Role in Colonization Among IBD Patients with Emphasis on Ulcerative Colitis [J].

Azimirad, Masoumeh ;

Gol, Sara Mohammad Ali ;

Javanmard, Ehsan ;

Mirjalali, Hamed ;

Yadegar, Abbas ;

Aghdaei, Hamid Asadzadeh ;

Shahrokh, Shabnam ;

Balaii, Hedieh ;

Sadeghi, Amir ;

Zali, Mohammad Reza .

TURKISH JOURNAL OF GASTROENTEROLOGY, 2021, 32 (06) :500-507

[7] Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome [J].

Barbara, G ;

Stanghellini, V ;

De Giorgio, R ;

Cremon, C ;

Cottrell, GS ;

Santini, D ;

Pasquinelli, G ;

Morselli-Labate, AM ;

Grady, EF ;

Bunnett, NW ;

Collins, SM ;

Corinalidesi, R .

GASTROENTEROLOGY, 2004, 126 (03) :693-702

[8] Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice [J].

Barbara, G ;

Vallance, BA ;

Collins, SM .

GASTROENTEROLOGY, 1997, 113 (04) :1224-1232

[9]

Barquero B, 2018, INT J RES UN MATH ED, V4, P8, DOI 10.1007/s40753-017-0067-0

[10] Post-infectious irritable bowel syndrome: Mechanistic insights into chronic disturbances following enteric infection [J].

Beatty, Jennifer K. ;

Bhargava, Amol ;

Buret, Andre G. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (14) :3976-3985

← 1 2 3 4 5 6 7 8 9 10 →