Hypolipidemic and cardioprotective effects of Ulva lactuca ethanolic extract in hypercholesterolemic mice

被引：12

作者：

Kammoun, Intissar ^{[1
,4
]}

Ben Salah, Hichem ^{[3
]}

Ben Saad, Hajer ^{[4
]}

Cherif, Boutheina ^{[5
]}

Droguet, Mickael ^{[6
]}

Magne, Christian ^{[7
]}

Kallel, Choumous ^{[8
]}

Boudawara, Ons ^{[9
]}

Hakim, Ahmed ^{[4
]}

Gharsallah, Neji ^{[2
]}

Ben Amara, Ibtissem ^{[1
]}

机构：

[1] Univ Sfax, Higher Inst Biotechnol Sfax, Unit Funct Genom & Plant Physiol, Sfax, Tunisia

[2] Univ Sfax, Fac Sci Sfax, Lab Biotechnol Appl Culture Improvement Plants, 99-UR-08-73, Sfax, Tunisia

[3] Univ Sfax, Fac Sci Sfax, Nat Subst Team, Lab Organ Chem LR17ES08, Sfax, Tunisia

[4] Univ Sfax, Fac Med, Lab Pharmacol, Sfax, Tunisia

[5] UJF, Natl Inst Hlth & Med Res INSERM U548, Dept Response & Cellular Dynam DRDC, Immunochem Lab,Commissariat CEA Grenoble, Grenoble, France

[6] Univ Western Brittany, Fac Med & Hlth Sci, Brest Inst Hlth Agron & Mat IBSAM, ORPHY,Optimizat Physiol Regulat,EA4324, Brest 3, France

[7] Univ Western Brittany, UFR Sci & Tech, EA 2219 Geoarchitecture, Brest 3, France

[8] CHU Habib Bourguiba, Hematol Lab, Sfax, Tunisia

[9] CHU Habib Bourguiba, Lab Anatomopathol, Sfax, Tunisia

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 124卷 / 04期

关键词：

Hypercholesterolemia; cardiotoxicity; phenolic compounds; Ulva lactuca; DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-HEART-DISEASE; ANTIOXIDANT ACTIVITY; PERTUSA CHLOROPHYTA; DIETARY FIBER; MARINE-ALGAE; OXIDATIVE STRESS; LIPID-METABOLISM; RAT MODEL; IN-VITRO;

D O I：

10.1080/13813455.2017.1401641

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Context: Hypercholesterolemia has significant cardiac consequences, since it is among the major risk factors of ischemic heart diseases. Objective: The aim was searching the cardioprotective effect of chemical constituents from the sea lettuce Ulva lactuca upon hypercholesterolemic regime in mice. Material and methods: Mice were randomly divided into three groups: untreated group, hypercholesterolemic group, and mice receiving 1% cholesterol associated with U. lactuca ethanolic extract. Results:In vitro study demonstrated that algal extract has antioxidant efficacy attributable to the presence of phenolic compounds. Additionally, the alga alleviated cardiotoxicity, as shown by the improvement of haematological parameters, white cell viability, heart oxidative stress, plasma biochemical parameters and index of atherogenesis. Gene expression of the proinflammatory cytokines TNF-alpha, IL-beta 1 and IL-6 significantly decreased in the heart of U. lactuca supplemented hypercholesterolemic animals. Conclusion: It was established that the green alga, thanks to its bioactive compounds, effectively counteracts cardiotoxic effects of hypercholesterolemic regime.

引用

页码：313 / 325

页数：13

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