2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as, broad-spectrum inhibitors of human herpesvirus polymerases

被引：41

作者：

Schnute, Mark E.

Anderson, David J.

Brideau, Roger J.

Ciske, Fred L.

Collier, Sarah A.

Cudahy, Michele M.

Eggen, MariJean

Genin, Michael J.

Hopkins, Todd A.

Judge, Thomas M.

Kim, Euibong J.

Knechtel, Mary L.

Nair, Sajiv K.

Nieman, James A.

Oien, Nancee L.

Scott, Allen

Tanis, Steven P.

Valliancourt, Valerie A.

Wathen, Michael W.

Wleber, Janet L.

机构：

[1] Pfizer Inc, Global Res & Dev, St Louis, MO 63017 USA

[2] Pfizer Inc, Global Res & Dev, Kalamazoo, MI 49007 USA

[3] Pfizer Inc, Global Res & Dev, Ann Arbor, MI 48105 USA

[4] Pfizer Inc, Global Res & Dev, San Diego, CA 92121 USA

[5] Pfizer Inc, Res API, Kalamazoo, MI 49007 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 12期

关键词：

cytomegalovirus; HCMV; varicella-zoster; VZV; HSV;

D O I：

10.1016/j.bmcl.2007.03.102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases. (c) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：3349 / 3353

页数：5

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