Paget disease of bone in Japanese patients: a report of three cases

被引：4

作者：

Nagano, Satoshi ^{[1
]}

Yokouchi, Masahiro ^{[1
]}

Nagayoshi, Ryusaku ^{[1
]}

Sasaki, Hiromi ^{[1
]}

Shimada, Hirofumi ^{[1
]}

Setoguchi, Takao ^{[1
]}

Ijiri, Kosei ^{[1
]}

Komiya, Setsuro ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Orthopaed Surg, Kagoshima 890, Japan

来源：

JOURNAL OF ORTHOPAEDIC SURGERY | 2013年 / 21卷 / 03期

关键词：

alkaline phosphatase; diphosphonates; osteitis deformans; MANAGEMENT; PATHOGENESIS;

D O I：

10.1177/230949901302100323

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Paget disease of bone (PDB) is a bone metabolic disorder causing pain, fractures, and deformity. Its incidence is estimated to be 1 to 2% in Caucasians older than 55 years, but in Asian populations the incidence is rare. We report on 2 female and one male Japanese patients aged 46 to 73 years with PDB. One patient had monostotic disease with pain around the shoulder and the other 2 were asymptomatic. All patients had elevated alkaline phosphatase (ALP) levels (range, 629-957 U/L). Two patients responded to oral bisphosphonate treatment and achieved normalised ALP levels and pain relief. One patient with polyostotic disease did not show any change in ALP levels. The diagnosis of the disease and the indications for bisphosphonate treatment are discussed.

引用

页码：375 / 379

页数：5

共 16 条

[1] FDG PET of primary benign and malignant bone tumors: Standardized uptake value in 52 lesions [J].