Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of Helicobacter pylori in smokers

Background: Our previous study demonstrated that Helicobacter pylori eradication was less effective in smokers than in non-smokers, Cetraxate is an antiulcer drug that increases gastric mucosal blood flow. Aim: To evaluate the effect of cetraxate combined with new triple therapy for the eradication of H. pylori in smokers. Methods: This study had a single-centre, double-blind, randomized non-placebo design. A total of 106 consecutive H. pylori-positive smoking patients were randomly allocated to one of two regimens: one group received omeprazole (20 mg), amoxycillin (1500 mg), and clarithromycin (600 mg) for 7 days (OAC, n = 55). The other group recieved DAC plus cetraxate (600 mg) for 7 days (OAC + CET, n = 51). The success of H. pylori eradication was evaluated by histology and the C-13- urea breath test at 4 weeks after completion of treatment, Results: By intention-to-treat analysis, the H. pylori eradication rate was 55% in the OAC group and 92% in the OAC + CET group (P < 0.01), By per protocol analysis, the H, pylori eradication rate was 58% in the OAC group and 94% in the OAC + CET group (P < 0.01). Conclusion: Cetraxate combined with new triple therapy increases the eradication of H. pylori in smokers.