The LuxS/AI-2 system of Streptococcus suis

被引：69
作者：
Wang, Yang [1 ]
Wang, Yuxin [1 ]
Sun, Liyun [1 ]
Grenier, Daniel [2 ]
Yi, Li [2 ,3 ]
机构：
[1] Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang, Peoples R China
[2] Univ Laval, Fac Med Dent, GREB, Quebec City, PQ, Canada
[3] Luoyang Normal Univ, Coll Life Sci, Luoyang, Peoples R China
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2018年 / 102卷 / 17期
基金：
中国国家自然科学基金;
关键词：
Streptococcus suis; Quorum sensing system; LuxS/AI-2; system; Drug resistance; S-RIBOSYLHOMOCYSTEINASE LUXS; QUORUM-SENSING PROTEIN; BIOFILM FORMATION; CRYSTAL-STRUCTURE; KEY ROLE; VIRULENCE; BACTERIA; MUTANS; AUTOINDUCER-2; SEROTYPE-2;
D O I：
10.1007/s00253-018-9170-7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Quorum sensing (QS) is an important protective mechanism that allows bacteria to adapt to its environment. A limited number of signal molecules play the key role of transmitting information in this mechanism. Signals are transmitted between individual bacterium through QS systems, resulting in the expression of specific genes. QS plays an important role in a variety of bacterial processes, including drug resistance, biofilm formation, motility, adherence, and virulence. Most Gram-positive and Gram-negative bacteria possess QS systems, mainly the LuxS/AI-2-mediated QS system. Evidence has been brought that LuxS/AI-2 system controls major virulence determinants in Streptococcus suis and, as such, the ability of this bacterial species to cause infections in humans and pigs. Understanding the S. suis LuxS/AI-2 system may open up novel avenues for decreasing the drug resistance and infectivity of S. suis. This article focuses on the progress made to date on the S. suis LuxS/AI-2-mediated QS system.
引用
收藏
页码：7231 / 7238
页数：8
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