Interplay between the human gut microbiome and host metabolism

被引：525

作者：

Visconti, Alessia ^{[1
]}

Le Roy, Caroline I. ^{[1
]}

Rosa, Fabio ^{[1
]}

Rossi, Niccolo ^{[1
,2
]}

Martin, Tiphaine C. ^{[1
,3
,4
]}

Mohney, Robert P. ^{[5
]}

Li, Weizhong ^{[6
,8
]}

de Rinaldis, Emanuele ^{[7
]}

Bell, Jordana T. ^{[1
]}

Venter, J. Craig ^{[6
,8
]}

Nelson, Karen E. ^{[6
,8
]}

Spector, Tim D. ^{[1
]}

Falchi, Mario ^{[1
]}

机构：

[1] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

[2] Univ Lisbon, Fac Sci, BioISI Biosyst & Integrat Sci Inst, Lisbon, Portugal

[3] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[5] Metabolon Inc, Morrisville, NC USA

[6] Human Longev Inc, San Diego, CA USA

[7] Sanofi, Cluster Precis Immunol, Immunol & Inflammat, Cambridge, MA USA

[8] J Craig Venter Inst, La Jolla, CA USA

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

BILE-ACID METABOLISM; METHANOBREVIBACTER-SMITHII; GENOME; METAGENOMICS; DETERMINANTS; DIVERSITY; BACTERIA;

D O I：

10.1038/s41467-019-12476-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human gut is inhabited by a complex and metabolically active microbial ecosystem. While many studies focused on the effect of individual microbial taxa on human health, their overall metabolic potential has been under-explored. Using whole-metagenome shotgun sequencing data in 1,004 twins, we first observed that unrelated subjects share, on average, almost double the number of metabolic pathways (82%) than species (43%). Then, using 673 blood and 713 faecal metabolites, we found metabolic pathways to be associated with 34% of blood and 95% of faecal metabolites, with over 18,000 significant associations, while species showed less than 3,000 associations. Finally, we estimated that the microbiome was involved in a dialogue between 71% of faecal, and 15% of blood, metabolites. This study underlines the importance of studying the microbial metabolic potential rather than focusing purely on taxonomy to find therapeutic and diagnostic targets, and provides a unique resource describing the interplay between the microbiome and the systemic and faecal metabolic environments.

引用

页数：10

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