共 68 条
Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d
被引:101
作者:

Green, TD
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机构: E Carolina Univ, Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA

Montefiori, DC
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机构: E Carolina Univ, Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA

Ross, TM
论文数: 0 引用数: 0
h-index: 0
机构: E Carolina Univ, Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA
机构:
[1] E Carolina Univ, Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA
[2] E Carolina Univ, Sch Med, Dept Microbiol & Immunol, Greenville, NC 27858 USA
[3] Duke Univ, Med Ctr, Dept Surg, Ctr AIDS Res, Durham, NC 27710 USA
关键词:
D O I:
10.1128/JVI.77.3.2046-2055.2003
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
DNA vaccines expressing the envelope (Env) protein of the human immunodeficiency virus have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies in a variety of animal models. In this study, the murine and human homologues of the complement component, C3d, were used in a DNA vaccine to enhance the titers of antibody to Env. Initially, plasmids expressing a secreted form of Env (sgp120) fused to one, two, or three copies of the murine homologue of CM (mC3d) were constructed. Mice were inoculated with four vaccinations of DNA or two DNA vaccinations, followed by two boosts of affinity-purified gp120 protein. Analyses of titers demonstrated that multiple copies of mC3d coupled to sgp120 induced long-lasting, high-titer anti-Env antibody. Priming mice with sgp120-mC3d-DNA, followed by inoculation of purified gp120 protein, elicited the strongest antibody titers; however, the avidity maturation of the antibody was accelerated in the mice inoculated with sgp120-mC3d(3)-DNA. In addition, DNAs expressing sgp120 fused to three copies of the human homologue of C3d (hC3d(3)) efficiently enhanced the anti-Env antibody in rabbits. Lastly, antisera from both mice and rabbits vaccinated with DNA expressing sgp120-C3d(3) elicited higher titers of neutralizing antibody than did nonfused forms of Env. These results indicate that C3d, conjugated to sgp120, enhances the antibody responses to Env compared to non-C3d fused forms of Env, and this approach may be one way to overcome the poor ability of DNA vaccines to generate antibodies to Env.
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页码:2046 / 2055
页数:10
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论文数: 0 引用数: 0
h-index: 0
机构:
ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Arshad, H
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ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Fouts, TR
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ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016

Moore, JP
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机构:
ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016 ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR,NEW YORK,NY 10016
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A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure
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Binley, JM
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Sanders, RW
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Clas, B
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Schuelke, N
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Master, A
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Guo, Y
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JOURNAL OF VIROLOGY,
2000, 74 (02)
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Binley, JM
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Sanders, RW
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Clas, B
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Schuelke, N
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Master, A
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Guo, Y
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Kajumo, F
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Anselma, DJ
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机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Maddon, PJ
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机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Olson, WC
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h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Moore, JP
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h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA
[10]
CD21 augments antigen presentation in immune individuals
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Boackle, SA
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Holers, VM
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Karp, DR
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EUROPEAN JOURNAL OF IMMUNOLOGY,
1997, 27 (01)
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Boackle, SA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TEXAS,SW MED CTR,SIMMONS ARTHRIT RES CTR,DALLAS,TX 75235

Holers, VM
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h-index: 0
机构: UNIV TEXAS,SW MED CTR,SIMMONS ARTHRIT RES CTR,DALLAS,TX 75235

Karp, DR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TEXAS,SW MED CTR,SIMMONS ARTHRIT RES CTR,DALLAS,TX 75235