Recent advances in microbial production of high-value compounds in the tetrapyrrole biosynthesis pathway

被引：18

作者：

Zhang, Jian ^{[1
]}

Cui, Zhiyong ^{[1
]}

Zhu, Yuan ^{[1
]}

Zhu, Ziwei ^{[1
]}

Qi, Qingsheng ^{[1
,2
]}

Wang, Qian ^{[1
,2
]}

机构：

[1] Shandong Univ, Natl Glycoengn Res Ctr, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China

[2] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China

来源：

BIOTECHNOLOGY ADVANCES | 2022年 / 55卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Tetrapyrroles; 5-aminolevulinic acid; Heme; Chlorophyll; Vitamin B-12; Microbial cell factory; 5-AMINOLEVULINIC ACID PRODUCTION; RHODOBACTER-SPHAEROIDES HEMA; RECOMBINANT ESCHERICHIA-COLI; HIGH-LEVEL PRODUCTION; CORYNEBACTERIUM-GLUTAMICUM; RHODOPSEUDOMONAS-PALUSTRIS; EFFICIENT PRODUCTION; CONTROL STRATEGY; VITAMIN-B-12; RIBOSWITCH;

D O I：

10.1016/j.biotechadv.2021.107904

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tetrapyrroles are essential metabolic components produced by almost all organisms, and they participate in various fundamental biological processes. Tetrapyrroles are used as pharmaceuticals, food additives, and nutraceuticals, as well as in agricultural applications. However, their production is limited by their low extraction yields from natural resources and by the complex reaction steps involved in their chemical synthesis. Through advances in metabolic engineering and synthetic biology strategies, microbial cell factories were developed as an alternative method for tetrapyrrole production. Herein, we review recent developments in metabolic engineering and synthetic biology strategies that promote the microbial production of high-value compounds in the tetrapyrrole biosynthesis pathway (e.g., 5-aminolevulinic acid, heme, bilins, chlorophyll, and vitamin B12). Furthermore, outstanding challenges to the microbial production of tetrapyrrole compounds, as well as their possible solutions, are discussed.

引用

页数：10