The metabolic syndrome: A tug-of-war with no winner

被引:19
作者
Brotman, DJ [1 ]
Girod, JP [1 ]
机构
[1] Cleveland Clin Fdn, Dept Gen Internal Med, Cleveland, OH 44195 USA
关键词
D O I
10.3949/ccjm.69.12.990
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The metabolic syndrome may be viewed as a state of insulin-counterregulatory overdrive: counterregulatory hormones and fatty acids chronically duel with insulin, causing a cascade of biochemical interactions resulting in insulin resistance, hypertension, and dyslipidemia. Even before beta cells fail and type 2 diabetes ensues, the deadly quartet is quietly rehearsing.
引用
收藏
页码:990 / 994
页数:5
相关论文
共 27 条
[21]   The glycemic index - Physiological mechanisms relating to obesity, diabetes, and cardiovascular disease [J].
Ludwig, DS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (18) :2414-2423
[22]   Vascular reactivity in acromegalic patients:: preliminary evidence for regional endothelial dysfunction and increased sympathetic vasoconstriction [J].
Maison, P ;
Démolis, P ;
Young, J ;
Schaison, G ;
Giudicelli, JF ;
Chanson, P .
CLINICAL ENDOCRINOLOGY, 2000, 53 (04) :445-451
[23]   Role of free fatty acids on cardiac autonomic nervous system in noninsulin-dependent diabetic patients: Effects of metabolic control [J].
Manzella, D ;
Barbieri, M ;
Rizzo, MR ;
Ragno, E ;
Passariello, N ;
Gambardella, A ;
Marfella, R ;
Giugliano, D ;
Paolisso, G .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (06) :2769-2774
[24]   EFFECT OF TRAINING ON THE DOSE-RESPONSE RELATIONSHIP FOR INSULIN ACTION IN MEN [J].
MIKINES, KJ ;
SONNE, B ;
FARRELL, PA ;
TRONIER, B ;
GALBO, H .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (02) :695-703
[25]   A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia [J].
Nambi, V ;
Hoogwerf, BJ ;
Sprecher, DL .
CLEVELAND CLINIC JOURNAL OF MEDICINE, 2002, 69 (12) :985-989
[26]  
Reaven Gerald M., 1996, New England Journal of Medicine, V334, P374
[27]   Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ [J].
Trayhurn, P ;
Beattie, JH .
PROCEEDINGS OF THE NUTRITION SOCIETY, 2001, 60 (03) :329-339