The metabolic syndrome: A tug-of-war with no winner

被引:19
作者
Brotman, DJ [1 ]
Girod, JP [1 ]
机构
[1] Cleveland Clin Fdn, Dept Gen Internal Med, Cleveland, OH 44195 USA
关键词
D O I
10.3949/ccjm.69.12.990
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The metabolic syndrome may be viewed as a state of insulin-counterregulatory overdrive: counterregulatory hormones and fatty acids chronically duel with insulin, causing a cascade of biochemical interactions resulting in insulin resistance, hypertension, and dyslipidemia. Even before beta cells fail and type 2 diabetes ensues, the deadly quartet is quietly rehearsing.
引用
收藏
页码:990 / 994
页数:5
相关论文
共 27 条
[1]   Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus [J].
Björntorp, P ;
Holm, G ;
Rosmond, R .
DIABETIC MEDICINE, 1999, 16 (05) :373-383
[2]  
Bjorntorp P, 1996, INT J OBESITY, V20, P291
[3]   Exercise and insulin sensitivity: A review [J].
Borghouts, LB ;
Keizer, HA .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2000, 21 (01) :1-12
[4]   Effects of counterregulatory hormones in a high-glycemic index diet [J].
Brotman, D .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (06) :695-695
[5]   Does central obesity reflect ''Cushing's disease of the omentum''? [J].
Bujalska, IJ ;
Kumar, S ;
Stewart, PM .
LANCET, 1997, 349 (9060) :1210-1213
[6]   Bottomed out: metabolic significance of the circadian trough in glucocorticoid concentrations [J].
Dallman, MF ;
Akana, SF ;
Bhatnagar, S ;
Bell, ME ;
Strack, AM .
INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (Suppl 2) :S40-S46
[7]   With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens [J].
Deuschle, M ;
Gotthardt, U ;
Schweiger, U ;
Weber, B ;
Korner, A ;
Schmider, J ;
Standhardt, H ;
Lammers, CH ;
Heuser, I .
LIFE SCIENCES, 1997, 61 (22) :2239-2246
[8]   Nonesterified fatty acids in blood pressure control and cardiovascular complications [J].
Brent M. Egan ;
Eddie L. Greene ;
Theodore L. Goodfriend .
Current Hypertension Reports, 2001, 3 (2) :107-116
[9]   Improvement in hypertension in patients with diabetes mellitus after kidney/pancreas transplantation [J].
Elliott, MD ;
Kapoor, A ;
Parker, MA ;
Kaufman, DB ;
Bonow, RO ;
Gheorghiade, M .
CIRCULATION, 2001, 104 (05) :563-569
[10]   REGULATION OF NUTRIENT METABOLISM AND ENERGY-EXPENDITURE [J].
FELBER, JP ;
GOLAY, A .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1995, 44 (02) :4-9