CCR5+CD8 T-cell levels and monocyte activation precede the onset of acute coronary syndrome in HIV-infected patients on antiretroviral therapy

被引：11

作者：

Tarancon-Diez, Laura ^{[1
,2
]}

De Pablo-Bernal, Rebeca S. ^{[1
,2
]}

Alvarez-Rios, Ana I. ^{[1
,2
]}

Rosado-Sanchez, Isaac ^{[1
,2
]}

Dominguez-Molina, Beatriz ^{[1
,2
]}

Genebat, Miguel ^{[1
,2
]}

Pacheco, Yolanda M. ^{[1
,2
]}

Luis Jimenez, Jose ^{[3
,4
]}

Angeles Munoz-Fernandez, M. ^{[3
,4
]}

Ruiz-Mateos, Ezequiel ^{[1
,2
]}

Leal, Manuel ^{[1
,2
]}

机构：

[1] Univ Seville, Virgen del Rocio Univ Hosp, Biomed Inst Seville, Lab Immunovirol,IBIS,CSIC,SAS, Seville, Spain

[2] Virgen del Rocio Univ Hosp, Dept Biochem, Seville, Spain

[3] Gen Univ Hosp Gregorio Maranon, Mol Immunobiol Lab, Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Spanish HIV HGM BioBank,Hlth Res Inst Gregorio Ma, Madrid, Spain

[4] Gen Univ Hosp Gregorio Maranon, Inst Hlth Carlos 3, Viral & Immune Infect Unit Ctr, Mol Immunobiol Lab, Majadahonda Campus, Madrid, Spain

来源：

THROMBOSIS AND HAEMOSTASIS | 2017年 / 117卷 / 06期

关键词：

HIV; CCR5; monocyte; vascular event; immune activation; PLASMACYTOID DENDRITIC CELLS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; INCREASED RISK; ATHEROSCLEROSIS; INFLAMMATION; MARKERS; PLAQUE; PROGRESSION; MARAVIROC;

D O I：

10.1160/TH16-11-0867

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute coronary syndrome (ACS) is nowadays one of the leading causes of morbid-mortality in HIV-infected population, but innate and adaptive immune mechanisms preceding this event are unknown. In this work we comprehensively and longitudinally observed, by multi parametric flow cytometry and following a case-control design, increased CCR5(+)CD8(+) T-cells levels and monocytes expressing activation and adhesion markers in HIV-infected patients who are going to suffer ACS. In addition, we found direct associations between activated CD8(+)T-cells and myeloid cells that were only statistically significant in the group of patients with ACS and in the follow up time point just before the ACS. Our data highlight the important role of CCR5 in the onset of ACS and suggest this receptor as a marker of cardiovascular risk and potential therapeutic target to prevent the development of such non-AIDS-related event in HIV-infected patients.

引用

页码：1141 / 1149

页数：9

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