Harnessing the Microbiome for Pancreatic Cancer Immunotherapy

被引：52

作者：

Vitiello, Gerardo A. ^{[1
]}

Cohen, Deirdre J. ^{[2
]}

Miller, George ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Surg, 435 East 30th St,4th Floor, New York, NY 10016 USA

[2] NYU, Langone Sch Med, Perlmutter Canc Ctr, 160 East 34th St, New York, NY 10016 USA

来源：

TRENDS IN CANCER | 2019年 / 5卷 / 11期

关键词：

CARCINOGENESIS; ONCOGENESIS; INDUCTION; BACTERIA; LIVER;

D O I：

10.1016/j.trecan.2019.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Late-stage pancreatic cancer harbors a fibrotic and immune-excluded tumor microenvironment that impedes immunotherapy success. A key to unlocking pancreatic cancer immunotherapy may be treating early-stage pancreatic cancer, when peripancreatic inflammation promoted by the microbiome potentiates oncogenic signaling and suppresses innate and adaptive immunity. Hence, understanding the role of microbiota in pancreatic cancer initiation, progression, and immunosuppression is crucial. We propose that not only are microbiota targets for immuno-modulation in this disease, but also that microbiome profiling has a potential role in pancreatic cancer screening. Furthermore, combining microbiome profiling with liquid and tissue biopsy may validate the early pancreatic cancer treatment approach of microbiome modulation and immunotherapy.

引用

页码：670 / 676

页数：7

共 49 条

[1] Pathobiology of Helicobacter pylori-Induced Gastric Cancer [J].

Amieva, Manuel ;

Peek, Richard M., Jr. .

GASTROENTEROLOGY, 2016, 150 (01) :64-78

[2]

[Anonymous], J CLIN ONCOL S

[3] Genomic analyses identify molecular subtypes of pancreatic cancer [J].

Bailey, Peter ;

Chang, David K. ;

Nones, Katia ;

Johns, Amber L. ;

Patch, Ann-Marie ;

Gingras, Marie-Claude ;

Miller, David K. ;

Christ, Angelika N. ;

Bruxner, Tim J. C. ;

Quinn, Michael C. ;

Nourse, Craig ;

Murtaugh, L. Charles ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Fink, Lynn ;

Holmes, Oliver ;

Chin, Vencssa ;

Anderson, Matthew J. ;

Kazakoff, Stephen ;

Leonard, Conrad ;

Newell, Felicity ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wilson, Peter J. ;

Cloonan, Nicole ;

Kassahn, Karin S. ;

Taylor, Darrin ;

Quek, Kelly ;

Robertson, Alan ;

Pantano, Lorena ;

Mincarelli, Laura ;

Sanchez, Luis N. ;

Evers, Lisa ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chantrill, Lorraine A. ;

Mawson, Amanda ;

Humphris, Jeremy ;

Chou, Angela ;

Pajic, Marina ;

Scarlett, Christopher J. .

NATURE, 2016, 531 (7592) :47-+

[4] Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities [J].

Balachandran, Vinod P. ;

Beatty, Gregory L. ;

Dougan, Stephanie K. .

GASTROENTEROLOGY, 2019, 156 (07) :2056-2072

[5] Smoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans [J].

Biedermann, Luc ;

Zeitz, Jonas ;

Mwinyi, Jessica ;

Sutter-Minder, Eveline ;

Rehman, Ateequr ;

Ott, Stephan J. ;

Steurer-Stey, Claudia ;

Frei, Anja ;

Frei, Pascal ;

Scharl, Michael ;

Loessner, Martin J. ;

Vavricka, Stephan R. ;

Fried, Michael ;

Schreiber, Stefan ;

Schuppler, Markus ;

Rogler, Gerhard .

PLOS ONE, 2013, 8 (03)

[6] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[7] Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer [J].

Bullman, Susan ;

Pedamallu, Chandra S. ;

Sicinska, Ewa ;

Claney, Thomas E. ;

Zhang, Xiaoyang ;

Cai, Diana ;

Neuberg, Donna ;

Huang, Katherine ;

Guevara, Fatima ;

Nelson, Timothy ;

Chipashvili, Otari ;

Hagan, Timothy ;

Walker, Mark ;

Ramachandran, Aruna ;

Diosdado, Begona ;

Serna, Garazi ;

Mulet, Nuria ;

Landolfi, Stefania ;

Ramon y Cajal, Santiago ;

Fasani, Roberta ;

Aguirre, Andrew J. ;

Ng, Kimmie ;

Elez, Elena ;

Ogino, Shuji ;

Tabernero, Josep ;

Fuchs, Charles S. ;

Hahn, William C. ;

Nuciforo, Paolo ;

Meyerson, Matthew .

SCIENCE, 2017, 358 (6369) :1443-+

[8] Liquid biopsy: monitoring cancer-genetics in the blood [J].

Crowley, Emily ;

Di Nicolantonio, Federica ;

Loupakis, Fotios ;

Bardelli, Alberto .

NATURE REVIEWS CLINICAL ONCOLOGY, 2013, 10 (08) :472-484

[9] The Microbiomes of Pancreatic and Duodenum Tissue Overlap and Are Highly Subject Specific but Differ between Pancreatic Cancer and Noncancer Subjects [J].

del Castillo, Erika ;

Meier, Richard ;

Chung, Mei ;

Koestler, Devin C. ;

Chen, Tsute ;

Paster, Bruce J. ;

Charpentier, Kevin P. ;

Kelsey, Karl T. ;

Izard, Jacques ;

Michaud, Dominique S. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2019, 28 (02) :370-383

[10] Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer [J].

Derosa, L. ;

Hellmann, M. D. ;

Spaziano, M. ;

Halpenny, D. ;

Fidelle, M. ;

Rizvi, H. ;

Long, N. ;

Plodkowski, A. J. ;

Arbour, K. C. ;

Chaft, J. E. ;

Rouche, J. A. ;

Zitvogel, L. ;

Zalcman, G. ;

Albiges, L. ;

Escudier, B. ;

Routy, B. .

ANNALS OF ONCOLOGY, 2018, 29 (06) :1437-1444

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