Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

被引：49

作者：

Benedek, Gil ^{[1
,2
]}

Zhang, Jun ^{[1
,2
]}

Bodhankar, Sheetal ^{[1
,2
]}

Ha Nguyen ^{[1
,2
]}

Kent, Gail ^{[1
,2
]}

Jordan, Kelley ^{[1
,2
]}

Manning, Dustin ^{[1
,2
]}

Vandenbark, Arthur A. ^{[1
,2
,3
]}

Offner, Halina ^{[1
,2
,4
]}

机构：

[1] VA Portland Hlth Care Syst, Neuroimmunol Res, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[4] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 293卷

关键词：

Estrogen; EAE; Regulatory B cell; Microglia; IL-10; IFN-gamma; DEFICIENT MICE; T-CELLS; ALTERNATIVE ACTIVATION; CNS REMYELINATION; SEX-DIFFERENCES; RECEPTOR-ALPHA; SCLEROSIS; INFLAMMATION; MACROPHAGES; INDUCTION;

D O I：

10.1016/j.jneuroim.2016.02.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-gamma dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection. (C) 2016 Elsevier B.V. All rights reserved.

引用

收藏

页码：45 / 53

页数：9

相关论文

共 50 条

[41] Mitochondrial Uncoupler, 2,4-Dinitrophenol, Reduces Spinal Cord Paralysis and Retinal Ganglion Cell Loss in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis [J].

O'Neill, Nuala ;

Khan, Reas S. ;

Abd Alhadi, Suad ;

Dine, Kimberly E. ;

Geisler, John G. ;

Chaqour, Brahim ;

Ross, Ahmara G. ;

Shindler, Kenneth S. .

BIOMOLECULES, 2025, 15 (02)

[42] Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway [J].

Huang, Jing ;

Hu, Xiaohui ;

Li, Juanqin ;

Gong, Daokai .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 (09) :6647-6659

[43] Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice [J].

Fu, Gui-Qiang ;

Wang, Yang-Yang ;

Xu, Yao-Mei ;

Bian, Ming -Ming ;

Zhang, Lin ;

Yan, Hua-Zheng ;

Gao, Jian-Xiong ;

Li, Jing-Lu ;

Chen, Yu-Qing ;

Zhang, Nan ;

Ding, Shu-Qin ;

Wang, Rui ;

Li, Jiang-Yan ;

Hu, Jian-Guo ;

Lu, He Zuo .

EXPERIMENTAL NEUROLOGY, 2024, 377

[44] RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF-κB pathway in oral squamous cell carcinoma [J].

Dan, Hongxia ;

Liu, Sai ;

Liu, Jiajia ;

Liu, Dongjuan ;

Yin, Fengying ;

Wei, Zihao ;

Wang, Jiongke ;

Zhou, Yu ;

Jiang, Lu ;

Ji, Ning ;

Zeng, Xin ;

Li, Jing ;

Chen, Qianming .

MOLECULAR ONCOLOGY, 2020, 14 (04) :795-807

[45] Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th) 1, Th2, Th17, and regulatory T cell responses [J].

Wei Mingyan ;

Yang Tao ;

Li Qian ;

Zhou Dongdong ;

Du Zongpan ;

Fan Yongping .

JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2019, 39 (06) :809-817

[46] 2-Bromo-1,4-Naphthalenedione promotes CD8+ T cell expansion and limits Th1/Th17 to mitigate experimental autoimmune encephalomyelitis [J].

Yang, Cuixia ;

Ma, Yuanchen ;

Lu, Qiying ;

Qu, Yuliang ;

Li, Yuantao ;

Cheng, Shimei ;

Xiao, Chongjun ;

Chen, Jinshuo ;

Wang, Chuangjia ;

Wang, Feng ;

Xiang, Andy Peng ;

Huang, Weijun ;

Tang, Xiaorong ;

Zheng, Haiqing .

JOURNAL OF NEUROINFLAMMATION, 2024, 21 (01)

[47] Absence of host NF-κB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization [J].

Theresa Barberi ;

Allison Martin ;

Rahul Suresh ;

David J. Barakat ;

Sarah Harris-Bookman ;

Charles G. Drake ;

Michael Lim ;

Alan D. Friedman .

Cancer Immunology, Immunotherapy, 2018, 67 :1491-1503

[48] MC5r and A2Ar Deficiencies During Experimental Autoimmune Uveitis Identifies Distinct T cell Polarization Programs and a Biphasic Regulatory Response [J].

Lee, Darren J. ;

Preble, Janine ;

Lee, Stacey ;

Foster, C. Stephen ;

Taylor, Andrew W. .

SCIENTIFIC REPORTS, 2016, 6

[49] Naoxueshu oral liquid promotes hematoma absorption by targeting CD36 in M2 microglia via TLR4/MyD88/NF-?B signaling pathway in rats with intracerebral hemorrhage [J].

Li, Ruoqi ;

Song, Meiying ;

Zheng, Yingyi ;

Zhang, Jiaxue ;

Zhang, Shanshan ;

Fan, Xiang .

JOURNAL OF ETHNOPHARMACOLOGY, 2024, 319

[50] Peimine promotes microglial polarization to the M2 phenotype to attenuate drug-resistant epilepsy through suppressing the TLR4/ NF-κB/HIF-1α signaling pathway in a rat model and in BV-2 microglia [J].

Liu, Chongchong ;

Sun, Jiangyan ;

Shen, Xiaoming ;

Li, Shefang ;

Luo, Sha ;

Chen, Na ;

Zhang, Yunke .

HELIYON, 2024, 10 (15)

← 1 2 3 4 5 →