Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

被引：49
作者：
Benedek, Gil [1 ,2 ]
Zhang, Jun [1 ,2 ]
Bodhankar, Sheetal [1 ,2 ]
Ha Nguyen [1 ,2 ]
Kent, Gail [1 ,2 ]
Jordan, Kelley [1 ,2 ]
Manning, Dustin [1 ,2 ]
Vandenbark, Arthur A. [1 ,2 ,3 ]
Offner, Halina [1 ,2 ,4 ]
机构：
[1] VA Portland Hlth Care Syst, Neuroimmunol Res, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Dept Neurol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA
[3] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA
[4] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 293卷
关键词：
Estrogen; EAE; Regulatory B cell; Microglia; IL-10; IFN-gamma; DEFICIENT MICE; T-CELLS; ALTERNATIVE ACTIVATION; CNS REMYELINATION; SEX-DIFFERENCES; RECEPTOR-ALPHA; SCLEROSIS; INFLAMMATION; MACROPHAGES; INDUCTION;
D O I：
10.1016/j.jneuroim.2016.02.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-gamma dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：45 / 53
页数：9
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