Lignans from the seeds of Arctium lappa L. (burdock) and their inhibitory effects on nitric oxide production

被引：5

作者：

Qin, Zhi-Bin ^{[1
,2
,3
]}

Ding, Lin-Fen ^{[1
,2
]}

Wang, Xue ^{[1
,2
]}

Huang, Li-Jia ^{[1
,2
]}

Liang, Meng-jie ^{[1
,2
]}

Bin, Jie ^{[4
]}

Luo, Na ^{[1
,2
]}

Deng, Liang ^{[1
,2
]}

Guo, Ya-Dong ^{[1
,2
]}

机构：

[1] Kunming Med Univ, Sch Pharmaceut Sci, 1168 Western Chunrong Rd, Kunming 650500, Yunnan, Peoples R China

[2] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, 1168 Western Chunrong Rd, Kunming 650500, Yunnan, Peoples R China

[3] Xian 3 Hosp, Xian 710018, Shaanxi, Peoples R China

[4] Honghe Hlth Vocat Coll, Honghe 661199, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2019年 / 34卷

关键词：

Arctium lappa; Compositae; Sesquiligans; Dilignans; Anti-inflammatory; DIFFERENTIATION-INDUCERS; DERIVATIVES; ROOTS;

D O I：

10.1016/j.phytol.2019.09.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Arctium lappa, commonly known as burdock, is being promoted as a healthy and nutritive food in Chinese societies. This study investigated the roots, seeds, and leaves of burdock in view of its popular uses in traditional Chinese medicine. Seven compounds, including three new ones, were isolated from the seeds of Arctium lappa. Structures of these compounds were examined by conducting extensive spectroscopic analysis. Biological analysis showed that compounds 4, 5, 6, and 7 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, and the IC50 values were in the range of 14.7-18.3 mu M.

引用

页码：43 / 49

页数：7

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