PHF10 Isoforms Are Phosphorylated in the PBAF Mammalian Chromatin Remodeling Complex

被引：5

作者：

Brechalov, A. V. ^{[1
,2
]}

Valieva, M. E. ^{[1
]}

Georgieva, S. G. ^{[1
,2
]}

Soshnikova, N. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia

[2] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

来源：

MOLECULAR BIOLOGY | 2016年 / 50卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

PHF10; protein isoforms; chromatin remodeling; SWI/SNF; chromatin-remodeling complex; posttranslational modifications; protein phosphorylation; gene expression; COACTIVATOR; SUBUNIT; BRAHMA;

D O I：

10.1134/S0026893316010039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin remodeling complex PBAF(SWI/SNF) alters the structure of chromatin and controls gene expression. PHF10 is a specific subunit of PBAF complex and is expressed as four isoforms in mammalian cells. We demonstrated that all isoforms are expressed in various human cell types of different histological origins. All four isoforms are extensively phosphorylated and their phosphorylation level is depended on the cell type. Phosphorylation of PHF10 isoforms occurs while they are incorporated as a subunit of the PBAF complex, and therefore phosphorylation of PHF10 isoforms may play an essential role in regulation of PBAF complex's function and mechanism of action.

引用

页码：278 / 283

页数：6