Functionalisation of nanoparticles for biomedical applications

被引：544

作者：

Thanh, Nguyen T. K. ^{[1
,2
]}

Green, Luke A. W. ^{[1
,2
]}

机构：

[1] Royal Inst Great Britain, Davy Faraday Res Labs, London W1S 4BS, England

[2] UCL, Dept Phys & Astron, London WC1E 6BT, England

来源：

NANO TODAY | 2010年 / 5卷 / 03期

关键词：

Noble metal; Nanoparticles; Quantum dot; Magnetism; Fluorescence; Biofunctionalisation; Biomedicine; Synthesis; IRON-OXIDE NANOPARTICLES; MONODISPERSE GOLD NANOPARTICLES; SCATTERING SUBMICROSCOPIC PARTICLES; STARCH VERMICELLI TEMPLATE; HIGHLY FLUORESCENT ANALOGS; SURFACE-PLASMON RESONANCE; SIZE-CONTROLLED SYNTHESIS; SOLUBLE QUANTUM DOTS; ONE-STEP SYNTHESIS; ONE-POT SYNTHESIS;

D O I：

10.1016/j.nantod.2010.05.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoparticles with cores composed of inorganic materials such as noble, magnetic metals, their alloys and oxides, and semiconductors have been most studied and have vast potential for application in many different areas of biomedicine, from diagnostics to treatment of diseases. The effects of nanoparticles must be predictable and controllable, and deliver the desired result with minimum cytotoxicity. These criteria can be met by careful tailoring of the ligand shell, allowing stabilisation, specific targeting and recognition of biochemical species. For these reasons, this review is focused on the synthesis and biofunctionalisation of inorganic metal, semiconductor and magnetic nanoparticles for biomedical applications. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：213 / 230

页数：18

共 237 条

[1] Functionalization of thioctic acid-capped gold nanoparticles for specific immobilization of histidine-tagged proteins [J].