Oxidation-sensitive polymeric nanoparticles

被引:130
作者
Rehor, A
Hubbell, JA
Tirelli, N
机构
[1] Swiss Fed Inst Technol, ETH, Inst Biomed Engn, CH-8044 Zurich, Switzerland
[2] Swiss Fed Inst Technol, ETH, Dept Mat, CH-8044 Zurich, Switzerland
[3] Univ Manchester, Sch Pharm, Manchester M13 9PL, Lancs, England
[4] Univ Manchester, Ctr Mol Mat, Manchester M13 9PL, Lancs, England
关键词
D O I
10.1021/la0478043
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers specifically suitable for hydrophobic molecules. Exploiting the living emulsion polymerization of episulfides, we have produced new cross-linked polysulfide nanoparticles. Here we demonstrate how this process allows the production of stable nanoparticles with a good control over their size and functionality. The nanoparticles showed negligible cytotoxicity on a fibroblast model; furthermore, they exhibited sensitivity to oxidative conditions, which first produce swelling and then solubilize the material.
引用
收藏
页码:411 / 417
页数:7
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