The unique role of natural killer T cells in the response to microorganisms

被引：362

作者：

Tupin, Emmanuel ^{[1
]}

Kinjo, Yuki ^{[1
]}

Kronenberg, Mitchell ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Dev Immunol, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 06期

关键词：

D O I：

10.1038/nrmicro1657

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Natural killer T (NKT) cells combine features of the innate and adaptive immune systems. Recently, it has become evident that these T cells have crucial roles in the response to infectious agents. The antigen receptor expressed by NKT cells directly recognizes unusual glycolipids that are part of the membrane of certain Gram-negative bacteria and spirochetes. Moreover, even in the absence of microbial glycolipid antigens, these T cells respond to innate cytokines produced by dendritic cells that have been activated by microbes. This indirect sensing of infection, by responding to cytokines from activated dendritic cells, allows NKT cells to react to a broad range of infectious agents.

引用

页码：405 / 417

页数：13

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