Vasoactive intestinal peptide-secreting tumors (VIPo-mas) are extremely rare and difficult to diagnose, The authors describe a patient who was found to have a VIPoma after 3 years of symptoms. Somatostatin receptor scintigraphy using indium-labeled octreotide localized her tumor and prompted a surgical resection, This is the preferred imaging study for the earliest, most accurate, and cost-effective identification of VIPomas and their metastases.