Influenza A M2 transmembrane domain tunes its conformational heterogeneity and structural plasticity in the lipid bilayer by forming loop structures

被引：18
作者：
Liu, Yue
Tan, Junjun
Zhang, Jiahui
Li, Chuanzhao
Luo, Yi
Ye, Shuji [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 46期
关键词：
SOLID-STATE NMR; PROTON CHANNEL; VIBRATIONAL SPECTROSCOPY; SUM-FREQUENCY; CONDUCTION MECHANISM; HELIX TILT; VIRUS; MEMBRANE; ORIENTATION; ACTIVATION;
D O I：
10.1039/c8cc01533c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We discovered for the first time that the influenza A virus M2TM tunes its conformational heterogeneity and structural plasticity to respond to environmental cues by undergoing a helix-to-loop transition, resolving controversies regarding the mechanism of proton conduction and plasticity of the M2TM in lipid bilayers.
引用
收藏
页码：5903 / 5906
页数：4
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